Pro Dynam

Pro Dynam Uses, Dosage, Side Effects, Food Interaction and all others data.

A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822)

Pro Dynam is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

Pro Dynam
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Pro Dynam
Availability	Discontinued
Generic	Phenylbutazone
Phenylbutazone Other Names	Fenilbutazona, Phenbutazone, Phenylbutazon, Phenylbutazone, Phénylbutazone, Phenylbutazonum
Type
Formula	C₁₉H₂₀N₂O₂
Weight	Average: 308.3743 Monoisotopic: 308.152477894
Groups	Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country	United Kingdom
Last Updated:	September 19, 2023 at 7:00 am

Uses

Pro Dynam is an NSAID used to treat backache and ankylosing spondylitis.

For the treatment of backache and ankylosing spondylitis

Pro Dynam is also used to associated treatment for these conditions: Inflammation, Pain, Arthritic pain

How Pro Dynam works

Pro Dynam binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues.

Toxicity

Oral, LD₅₀ = 238 mg/kg (mouse); Oral, LD₅₀ = 781 mg/kg (rabbit); Oral, LD₅₀ = 245 mg/kg (rat); Oral, LD₅₀ = 375 mg/kg (rat)

Food Interaction

Avoid alcohol.
Take with food. Food reduces irritation.

Pro Dynam Hypertension interaction

[Moderate] Nonsteroidal anti-inflammatory drugs (NSAIDs), including topicals, can lead to new onset of hypertension or worsening of preexisting hypertension, either of which can contribute to the increased incidence of cardiovascular events.

NSAIDs should be used with caution in patients with hypertension.

Blood pressure should be monitored closely during the initiation of NSAID therapy and throughout the course of therapy.