Pro Dynam

Pro Dynam Uses, Dosage, Side Effects, Food Interaction and all others data.

A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822)

Pro Dynam is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

Trade Name Pro Dynam
Availability Discontinued
Generic Phenylbutazone
Phenylbutazone Other Names Fenilbutazona, Phenbutazone, Phenylbutazon, Phenylbutazone, Phénylbutazone, Phenylbutazonum
Type
Formula C19H20N2O2
Weight Average: 308.3743
Monoisotopic: 308.152477894
Groups Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country United Kingdom
Last Updated: September 19, 2023 at 7:00 am
Pro Dynam
Pro Dynam

Uses

Pro Dynam is an NSAID used to treat backache and ankylosing spondylitis.

For the treatment of backache and ankylosing spondylitis

Pro Dynam is also used to associated treatment for these conditions: Inflammation, Pain, Arthritic pain

How Pro Dynam works

Pro Dynam binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues.

Toxicity

Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)

Food Interaction

  • Avoid alcohol.
  • Take with food. Food reduces irritation.

Pro Dynam Hypertension interaction

[Moderate] Nonsteroidal anti-inflammatory drugs (NSAIDs), including topicals, can lead to new onset of hypertension or worsening of preexisting hypertension, either of which can contribute to the increased incidence of cardiovascular events.

NSAIDs should be used with caution in patients with hypertension.

Blood pressure should be monitored closely during the initiation of NSAID therapy and throughout the course of therapy.

Pro Dynam Disease Interaction

Moderate: heart failure, hyperkalemia, hypertension

Innovators Monograph

You find simplified version here Pro Dynam

*** Taking medicines without doctor's advice can cause long-term problems.
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