Probiol

Probiol Uses, Dosage, Side Effects, Food Interaction and all others data.

Benzyl benzoate is an acaricide that is used in the treatment of scabies. Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.

Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.

Probiol
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Probiol
Generic	Benzyl Benzoate
Benzyl Benzoate Other Names	Acarobenzyl, Benylate, Benzevan, Benzoate de benzyle, Benzoesäurebenzylester, Benzoic acid phenylmethylester, Benzyl benzoat, Benzyl benzoate, Benzylis benzoas, Phenylmethyl benzoate
Type	Emul
Formula	C₁₄H₁₂O₂
Weight	Average: 212.2439 Monoisotopic: 212.083729628
Groups	Approved
Therapeutic Class	Parasiticidal preparations, Topical Antifungal preparations
Manufacturer	Progressive Associates
Available Country	Pakistan
Last Updated:	September 19, 2023 at 7:00 am

Uses

Probiol is used for scabies

Probiol is also used to associated treatment for these conditions: Lice, Scabies

How Probiol works

Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.

Dosage

Probiol dosage

Adult:Apply 3 times at 12 hourly intervals over the whole body, wash-off 12 hr after the last application.

Side Effects

Irritant to eyes and mucous membranes, allergic dermatitis reactions, drying effects in the elderly.

Toxicity

Oral, rabbit: LD₅₀ = 1680 mg/kg; Skin, rabbit: LD₅₀ = 4000 mg/kg. Symptoms of overdose include blister formation, crusting, itching, oozing, reddening, or scaling of skin; difficulty in urinating (dribbling); jerking movements; sudden loss of consciousness.

Precaution

Prevent drug from entering the eyes, elderly (drying effects).

Interaction

Irritant to eyes and mucous membranes, allergic dermatitis reactions, drying effects in the elderly.

Elimination Route

No data are available on percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however the amount was not quantified.