Probiol Emulsion

Probiol Emulsion Uses, Dosage, Side Effects, Food Interaction and all others data.

Benzyl benzoate is an acaricide that is used in the treatment of scabies. Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.

Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.

Trade Name Probiol Emulsion
Generic Benzyl Benzoate
Benzyl Benzoate Other Names Acarobenzyl, Benylate, Benzevan, Benzoate de benzyle, Benzoesäurebenzylester, Benzoic acid phenylmethylester, Benzyl benzoat, Benzyl benzoate, Benzylis benzoas, Phenylmethyl benzoate
Weight 25%w/v
Type Lotion
Formula C14H12O2
Weight Average: 212.2439
Monoisotopic: 212.083729628
Groups Approved
Therapeutic Class Parasiticidal preparations, Topical Antifungal preparations
Manufacturer Progressive Laboratories
Available Country Pakistan
Last Updated: September 19, 2023 at 7:00 am
Probiol Emulsion
Probiol Emulsion

Uses

Probiol Emulsion is used for scabies

Probiol Emulsion is also used to associated treatment for these conditions: Lice, Scabies

How Probiol Emulsion works

Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.

Dosage

Probiol Emulsion dosage

Adult:Apply 3 times at 12 hourly intervals over the whole body, wash-off 12 hr after the last application.

Side Effects

Irritant to eyes and mucous membranes, allergic dermatitis reactions, drying effects in the elderly.

Toxicity

Oral, rabbit: LD50 = 1680 mg/kg; Skin, rabbit: LD50 = 4000 mg/kg. Symptoms of overdose include blister formation, crusting, itching, oozing, reddening, or scaling of skin; difficulty in urinating (dribbling); jerking movements; sudden loss of consciousness.

Precaution

Prevent drug from entering the eyes, elderly (drying effects).

Interaction

Irritant to eyes and mucous membranes, allergic dermatitis reactions, drying effects in the elderly.

Elimination Route

No data are available on percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however the amount was not quantified.

Pregnancy & Breastfeeding use

Pregnancy Category: Not Classified. FDA has not yet classified the drug into a specified pregnancy category.

Contraindication

Broken or irritated skin; neonates; pregnancy.

Storage Condition

Store below 25°C.

Innovators Monograph

You find simplified version here Probiol Emulsion

Probiol Emulsion contains Benzyl Benzoate see full prescribing information from innovator Probiol Emulsion Monograph, Probiol Emulsion MSDS, Probiol Emulsion FDA label

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0002448
http://classyfire.wishartlab.com/tax_nodes/C0002279
http://classyfire.wishartlab.com/tax_nodes/C0000176
http://classyfire.wishartlab.com/tax_nodes/C0001350
http://classyfire.wishartlab.com/tax_nodes/C0001097
http://classyfire.wishartlab.com/tax_nodes/C0000321
http://classyfire.wishartlab.com/tax_nodes/C0001238
http://classyfire.wishartlab.com/tax_nodes/C0001137
http://classyfire.wishartlab.com/tax_nodes/C0000323
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:41237
http://metacyc.org/META/new-image?type=COMPOUND&object=CPD-6443
http://www.hmdb.ca/metabolites/HMDB0014814
http://www.genome.jp/dbget-bin/www_bget?drug:D01138
http://www.genome.jp/dbget-bin/www_bget?cpd:C12537
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2345
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508023
https://www.chemspider.com/Chemical-Structure.13856959.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50134035
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=19044
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=41237
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1239
https://zinc.docking.org/substances/ZINC000000001021
http://www.pharmgkb.org/drug/PA164748881
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/BZM
https://www.drugs.com/cons/benzyl-benzoate-topical.html
https://en.wikipedia.org/wiki/Benzyl_benzoate
*** Taking medicines without doctor's advice can cause long-term problems.
Share