Profenamine
Profenamine Uses, Dosage, Side Effects, Food Interaction and all others data.
Profenamine is a medication derived from phenothiazine. It is primarily used as an antidyskinetic to treat parkinsonism. It is sold under the trade names Parsidol in the United States and Parsidan in Canada.
Ethopropazine, a phenothiazine and antidyskinetic, is used in the treatment of Parkinson's disease. By improving muscle control and reducing stiffness, this drug permits more normal movements of the body as the disease symptoms are reduced. It is also used to control severe reactions to certain medicines such as reserpine, phenothiazines, chlorprothixene, thiothixene, loxapine, and haloperidol. Unlike other NMDA antagonists, ethopropazine — because of its anticholinergic action — is largely devoid of neurotoxic side effects. Ethopropazine also has a slight antihistaminic and local anesthetic effect.
| Trade Name | Profenamine |
| Generic | Profenamine |
| Profenamine Other Names | Ethopropazine, Profenamina, Profenamine, Profénamine, Profenaminum |
| Type | |
| Formula | C19H24N2S |
| Weight | Average: 312.472 Monoisotopic: 312.166019468 |
| Protein binding | 93% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Profenamine is an antidyskinetic phenothiazine used to treat the symptoms of Parkinson's disease.
For use in the treatment of Parkinson's disease and also used to control severe reactions to certain medicines such as reserpine.
Profenamine is also used to associated treatment for these conditions: Extrapyramidal disorder caused by neuroleptic drugs without Tardive dyskinesia, Parkinson's Disease (PD)
How Profenamine works
Ethopropazine's antiparkinson action can be attributed to its anticholinergic properties. Ethopropazine partially blocks central (striatal) cholinergic receptors, thereby helping to balance cholinergic and dopaminergic activity in the basal ganglia; salivation may be decreased, and smooth muscle may be relaxed. Drug-induced extrapyramidal symptoms and those due to parkinsonism may be relieved, but tardive dyskinesia is not alleviated and may be aggravated by anticholinergic effects. Ethopropazine's local anesthetic effect is due to its antagonism of the NMDA glutamate receptor. Glutamate is recognized as an important transmitter in nociceptive pathways, and the N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor, in particular, has been implicated in the mediation of neuropathic pain. Excessive release of glutamate at NMDA receptors on dorsal horn neurons of the spinal cord results in hyperactivation and hypersensitivity of these receptors (perceived as hyperalgesia), thought to be an integral feature of neuropathic pain.
Toxicity
Symptoms of overdose include severe clumsiness or unsteadiness, severe drowsiness, severe dryness of mouth, nose, or throat, fast heartbeat, shortness of breath or troubled breathing, and warmth, dryness, and flushing of skin.
Food Interaction
No interactions found.Elimination Route
Well-absorbed from the gastrointestinal tract.
Half Life
1 to 2 hours
Innovators Monograph
You find simplified version here Profenamine
