Progen Syrup

Progen Syrup Uses, Dosage, Side Effects, Food Interaction and all others data.

A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States.

Progen Syrup belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour and over-stimulation may result in psychotic illness. Progen Syrup hydrochloride blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness. Progen Syrup has weak extrapyramidal and autonomic side effects which lead to its use in the elderly, for restless or psychotic patients. Its anti-psychotic effect is also weaker and it is not useful in general psychiatry.

Progen Syrup
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
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Trade Name	Progen Syrup
Availability	Discontinued
Generic	Promazine
Promazine Other Names	Promazin, Promazina, Promazine, Promazinum
Related Drugs	quetiapine, Abilify, Seroquel, aripiprazole, olanzapine, risperidone, haloperidol, prochlorperazine, Haldol, Compazine
Weight	5mg/5ml, 0mg/5ml
Type	Syrup
Formula	C₁₇H₂₀N₂S
Weight	Average: 284.419 Monoisotopic: 284.13471934
Protein binding	94%
Groups	Approved, Vet approved
Therapeutic Class
Manufacturer	Ardin Pharmaceuticals
Available Country	Pakistan
Last Updated:	September 19, 2023 at 7:00 am

Uses

Progen Syrup is a phenothiazine used to manage schizophrenia.

Used as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly.

Progen Syrup is also used to associated treatment for these conditions: Psychomotor Agitation, Psychosis, Schizophrenia, Violent Aggressive Behavior

How Progen Syrup works

Progen Syrup is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Progen Syrup's antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors. This may explain the lack of extrapyramidal effects. Progen Syrup does not appear to block dopamine within the tubero-infundibular tract, explaining the lower incidence of hyperprolactinemia than with typical antipsychotic agents or risperidone. Antagonism at muscarinic receptors, H1-receptors, and alpha(1)-receptors also occurs with promazine.

Toxicity

Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (such as gynaecomastia and menstrual disturbance), sensitivity to sunlight and haemolytic anaemia.