Progyluton Uses, Dosage, Side Effects and more
Norgestrel (and more specifically the active stereoisomer levonorgestrel) binds to the progesterone and estrogen receptors within the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like levonorgestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. Loss of the LH surge inhibits ovulation and thereby prevents pregnancy.
| Trade Name | Progyluton |
| Generic | Estradiol (Valerate) + Estradiol. + Norgestrel |
| Weight | 2mg, 0.5mg, |
| Type | Tablet |
| Therapeutic Class | |
| Manufacturer | Bayer Health Care |
| Available Country | Pakistan, Portugal |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Norgestrel in combination with ethinyl estradiol is used for the prevention of pregnancy in women who elect to use this product as a method of contraception.
Progyluton is also used to associated treatment for these conditions: Abnormal Uterine Bleeding, Endometriosis, Hypermenorrhea, Menstrual Distress (Dysmenorrhea), Polycystic Ovarian Syndrome, Emergency Contraception, Oral Contraceptives
How Progyluton works
Norgestrel (and more specifically the active stereoisomer levonorgestrel) binds to the progesterone and estrogen receptors within the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like levonorgestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. Loss of the LH surge inhibits ovulation and thereby prevents pregnancy.
Dosage
0.075 mg at same time each day
Side Effects
Edema, Weakness, Anorexia, Amenorrhea, Breakthrough bleeding, Change in menstrual flow, Spotting
Precaution
- Documented hypersensitivity
- Active or history of breast cancer
- Thrombophlebitis, DVT/PE, thrombogenic valvular disease
- Estrogen-dependent neoplasia
- Liver disease, liver tumors
- Undiagnosed abnormal vaginal bleeding, uncontrolled hypertension, diabetes mellitus with vascular involvement, jaundice with prior oral contraceptive use, pregnancy, smoking >15 cigarettes/d) and >35 yo, history of migraine w/ aura
- Serum levels near baseline 24 hr after ingestion, so rigid adherence to dosing schedule is essential for efficacy
- DM, asthma, cardiac dysfunction, irregular menstrual bleeding patterns, bone mineral density changes, depression, epilepsy, migraine, renal dysfunction
- Risk of ectopic pregnancy is 0.5%
Pregnancy & Breastfeeding use
Pregnancy Category: X
Lactation: unsafe
Contraindication
- Documented hypersensitivity
- Active or history of breast cancer
- Arterial thromboembolic disease (stroke, MI), thrombophlebitis, DVT/PE, thrombogenic valvular disease
- Estrogen-dependent neoplasia
- Liver disease, liver tumors
- Undiagnosed abnormal vaginal bleeding
- Uncontrolled hypertension
- Diabetes mellitus with vascular involvement
- Jaundice with prior oral contraceptive use, pregnancy, smoking >15 cigarettes/d) and >35 yo, history of migraine with aura
- Pregnancy or use as a diagnostic test for pregnancy
Storage Condition
Should be stored in cool and dry place
