Promal

Promal Uses, Dosage, Side Effects, Food Interaction and all others data.

Promal is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.

Promal is a biguanide derivative that is converted to an active metabolite called cycloguanil. It exerts its antimalarial action by inhibiting parasitic dihydrofolate reductase enzyme. It has causal prophylactic and suppressive activity against P. falciparum and cures the acute infection. It is also effective in suppressing the clinical attacks of vivax malaria. However it is slower compared to 4-aminoquinolines.

Trade Name Promal
Availability Unknown
Generic Proguanil
Proguanil Other Names Chlorguanide, Chloroguanide, Proguanil, Proguanile, Proguanilo, Proguanilum
Type Tablet
Formula C11H16ClN5
Weight Average: 253.731
Monoisotopic: 253.109423244
Protein binding

Approximately 75%

Groups Approved
Therapeutic Class
Manufacturer Astrum Healthcare Pvt Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Promal
Promal

Uses

Promal is a medication indicated for prophylaxis and treatment of Plasmodium falciparum malaria.

For the causal prevention and suppression of malaria caused by susceptible strains of P. falciparum and other species of Plasmodium found in some geographical areas of the world.

Promal is also used to associated treatment for these conditions: Malaria caused by Plasmodium falciparum, Acute, uncomplicated Malaria caused by plasmodium falciparum

How Promal works

Promal inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver.

Food Interaction

  • Take with food.

Elimination Route

Rapidly and well absorbed in humans following oral doses ranging from 50 to 500 mg.

Half Life

Approximately 20 hours

Innovators Monograph

You find simplified version here Promal

*** Taking medicines without doctor's advice can cause long-term problems.
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