Promal
Promal Uses, Dosage, Side Effects, Food Interaction and all others data.
Promal is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.
Promal is a biguanide derivative that is converted to an active metabolite called cycloguanil. It exerts its antimalarial action by inhibiting parasitic dihydrofolate reductase enzyme. It has causal prophylactic and suppressive activity against P. falciparum and cures the acute infection. It is also effective in suppressing the clinical attacks of vivax malaria. However it is slower compared to 4-aminoquinolines.
| Trade Name | Promal |
| Availability | Unknown |
| Generic | Proguanil |
| Proguanil Other Names | Chlorguanide, Chloroguanide, Proguanil, Proguanile, Proguanilo, Proguanilum |
| Type | Tablet |
| Formula | C11H16ClN5 |
| Weight | Average: 253.731 Monoisotopic: 253.109423244 |
| Protein binding | Approximately 75% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | Astrum Healthcare Pvt Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Promal is a medication indicated for prophylaxis and treatment of Plasmodium falciparum malaria.
For the causal prevention and suppression of malaria caused by susceptible strains of P. falciparum and other species of Plasmodium found in some geographical areas of the world.
Promal is also used to associated treatment for these conditions: Malaria caused by Plasmodium falciparum, Acute, uncomplicated Malaria caused by plasmodium falciparum
How Promal works
Promal inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver.
Food Interaction
- Take with food.
Promal Drug Interaction
Unknown: aspirin, tocilizumab, charcoal, epinephrine, ibuprofen, albumin human, contained in alcoholic beverages , zolpidem, aminocaproic acid, amoxicillin, RHO Immunoglobulin , celecoxib, fluconazole, heparin, metoprolol, metoprolol, acetaminophen, oseltamivir, cyanocobalamin, pyridoxine
Promal Disease Interaction
Elimination Route
Rapidly and well absorbed in humans following oral doses ranging from 50 to 500 mg.
Half Life
Approximately 20 hours
Innovators Monograph
You find simplified version here Promal
