Prosom

Prosom Uses, Dosage, Side Effects, Food Interaction and all others data.

A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam.

Prosom, a triazolobenzodiazepine derivative, is an oral hypnotic agent with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam.

Prosom
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Prosom
Availability	Prescription only
Generic	Estazolam
Estazolam Other Names	Estazolam, Estazolamum
Related Drugs	amitriptyline, lorazepam, melatonin, zolpidem, diphenhydramine, Ativan
Weight	1mg, 2mg,
Type	Oral tablet
Formula	C₁₆H₁₁ClN₄
Weight	Average: 294.738 Monoisotopic: 294.067224079
Protein binding	93% protein bound, independant of concentration.
Groups	Approved, Illicit
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Prosom is a benzodiazepine used for the short-term management of insomnia.

For the short-term management of insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings, and/or early morning awakenings.

Prosom is also used to associated treatment for these conditions: Insomnia

How Prosom works

Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABA_A) receptors, this enhances the effects GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.

Toxicity

Symptoms of overdose include confusion, depressed breathing, drowsiness and eventually coma, lack of coordination, and slurred speech.

Food Interaction

Avoid alcohol.
Take with or without food. The absorption is unaffected by food.

Prosom Alcohol interaction

[Moderate] GENERALLY AVOID:

Acute ethanol ingestion may potentiate the CNS effects of many benzodiazepines.

Tolerance may develop with chronic ethanol use.

The mechanism may be decreased clearance of the benzodiazepines because of CYP450 hepatic enzyme inhibition.

Also, it has been suggested that the cognitive deficits induced by benzodiazepines may be increased in patients who chronically consume large amounts of alcohol.

Patients should be advised to avoid alcohol during benzodiazepine therapy.

Prosom Drug Interaction

Moderate: aripiprazole, aripiprazole, zolpidem, zolpidem, duloxetine, duloxetine, eszopiclone, eszopiclone, pregabalin, pregabalin, quetiapine, quetiapine, alprazolam, alprazolamUnknown: amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, cholecalciferol, cholecalciferol, lisdexamfetamine, lisdexamfetamine

Prosom Disease Interaction

Major: acute alcohol intoxication, closed-angle glaucoma, drug dependence, renal/liver disease, respiratory depression, seizuresModerate: depression, obesity, paradoxical reactions

Elimination Route

Tablets have been found to be equivalent in absorption to an orally administered solution of estazolam. In healthy subjects who received up to three times the recommended dose, peak estazolam plasma concentrations occurred within two hours after dosing (range 0.5 to 6.0 hours) and were proportional to the administered dose, suggesting linear pharmacokinetics over the dosage range tested.

Half Life

The range of estimates for the mean elimination half-life of estazolam varies from 10 to 24 hours.

Elimination Route

Prosom is extensively metabolized. The elimination of the parent drug takes place via hepatic metabolism of estazolam to hydroxylated and other metabolites that are eliminated largely in the urine both free and conjugated. Less than 5% of a 2 mg dose of estazolam was excreted unchanged in the urine, with only 4% of the dose appearing in the feces. Radiolabel mass balance studies indicate that the main route of excretion is via the kidneys. After 5 days, 87% of the administered radioactivity was excreted in human urine. Less than 4% of the dose was excreted unchanged.