Prostin F2 Alpha

Prostin F2 Alpha Uses, Dosage, Side Effects, Food Interaction and all others data.

Prostin F2 Alpha is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.

Prostin F2 Alpha is equivalent to prostaglandin E2 (PGE2). It stimulates labor and delivery by stimulating the uterine, and thus terminates pregnancy. Prostin F2 Alpha is also capable of stimulating the smooth muscle of the gastrointestinal tract of man. This activity may be responsible for the vomiting and/or diarrhea that is not uncommon when dinoprostone is used to terminate pregnancy.

Trade Name Prostin F2 Alpha
Generic Dinoprostone
Dinoprostone Other Names (15S)-prostaglandin E2, Dinoproston, Dinoprostona, Dinoprostone, Dinoprostonum, PGE2, Prostaglandin E2
Weight 5mg/ml,
Type Injection
Formula C20H32O5
Weight Average: 352.4651
Monoisotopic: 352.224974134
Protein binding

73%, to albumin

Groups Approved
Therapeutic Class
Manufacturer Pfizer Laboratories Ltd,
Available Country Pakistan,
Last Updated: September 19, 2023 at 7:00 am
Prostin F2 Alpha
Prostin F2 Alpha

Uses

Prostin F2 Alpha is a prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease.

For the termination of pregnancy during the second trimester (from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period), as well as for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period. Also used in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole). Other indications include improving the cervical inducibility (cervical "ripening") in pregnant women at or near term with a medical or obstetrical need for labor induction, and the management of postpartum hemorrhage.

Prostin F2 Alpha is also used to associated treatment for these conditions: Gestational Trophoblastic Disease, Induction of cervix ripening therapy, Medically induced abortion, Uterus evacuation

How Prostin F2 Alpha works

Prostin F2 Alpha administered intravaginally stimulates the myometrium of the gravid uterus to contract in a manner that is similar to the contractions seen in the term uterus during labor, resulting in the evacuation of the products of conception from the uterus. It is believed that dinoprostone exerts its uterine effects via direct myometrial stimulation, but the exact mechanism of action is unkown. Other suggested mechanisms include the regulation of cellular membrane calcium transport and of intracellular concentrations of cyclic 3',5'-adenosine monophosphate. Prostin F2 Alpha also appears to produce local cervical effects including softening, effacement, and dilation. The exact mechanism of action for this effect is also unknown, but it has been suggested that this effect may be associated with collagen degradation caused by secretion of the enzyme collagenase as a partial response to locally administered dinoprostone.

Toxicity

Oral, mouse: LD50 = 750 mg/kg; Oral, rat: LD50 = 500 mg/kg.

Food Interaction

No interactions found.

Elimination Route

Absorbed at a rate of 0.3 mg per hour over 12 hours while the vaginal system is in place.

Half Life

Less than 5 minutes.

Elimination Route

The major route of elimination of the products of PGE2 metabolism is the kidneys.

Innovators Monograph

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https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15551
http://www.genome.jp/dbget-bin/www_bget?cpd:C00584
http://www.lipidmaps.org/data/LMSDRecord.php?LMID=LMFA03010003
http://www.hmdb.ca/metabolites/HMDB0001220
http://www.genome.jp/dbget-bin/www_bget?drug:D00079
http://www.genome.jp/dbget-bin/www_bget?cpd:C00584
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5280360
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505549
https://www.chemspider.com/Chemical-Structure.4444059.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35847
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=3478
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=15551
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL548
https://zinc.docking.org/substances/ZINC000003830713
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000360
http://www.pharmgkb.org/drug/PA449345
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1916
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/P2E
http://www.rxlist.com/cgi/generic/dinoprostone.htm
https://www.drugs.com/cdi/dinoprostone-gel.html
https://en.wikipedia.org/wiki/Prostaglandin_E2
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