Protein S
Protein S Uses, Dosage, Side Effects, Food Interaction and all others data.
Protein S is a vitamin K-dependent plasma glycoprotein which has antcoagulant properties . It serves as a negative feedback mechanism in the coagulation cascade.
Protein S acts as an anticoagulant serves as a negative feedback mechanism in the coagulation cascade .
| Trade Name | Protein S |
| Generic | Protein S human |
| Protein S human Other Names | Protein S, Protein S (human), Vitamin K-dependent protein S |
| Type | |
| Weight | 75123.0 Da |
| Protein binding | Approximately 60% of protein S is bound to C4b-binding protein in systemic circulation . |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Protein S is a medication used for emergency reversal of coagulation factor deficiency in vitamin K antagonist therapy.
For use in the emergency reversal of coagulation factor deficiency in patients recieving vitamin K antagonist therapy . Protein S is administered as part of a cocktail containing several other coagulation factors.
Protein S is also used to associated treatment for these conditions: Vitamin K antagonist induced major bleeding
How Protein S works
Thrombin converts protein C to activated protein C (APC) . Protein S functions as a cofactor for APC and together they proteolytically cleave factor Va and VIIIa . This inhibits the activities of the prothrombinase and tenase complexes respectively and leads to a reduction in thrombin generation. The reduction in thrombin generation suppresses the coagulation cascade preventing additional clotting from occuring. Protein S is suggested to inhibit factors Va and Xa through protein-protein interactions . Protein S is also suggested to inhibit production of factor Xa by the tenase complex by competing for binding to phospholipids via its gamma-carboxyglutamic acid domain.
Protein S is thought to exert an anti-inflammatory effect in addition to its anticoagulant properties. The protein S-C4b-binding protein complex is believed to bind to phosphotidylserines on the cell membranes of apoptotic cells and interact with macrophages, signalling them to phagocytose the cell before it can rupture .
Food Interaction
- Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.
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