Pryzm

Pryzm Uses, Dosage, Side Effects, Food Interaction and all others data.

Cefetamet Pivoxil is an oral third-generation cephalosporin antibiotic which is hydrolyzed to form the active agent, Cefetamet. It is a bactericidal antibiotic; kills bacteria by interfering with bacterial cell wall synthesis due to inhibition of Transpeptidase enzyme. Cefetamet has excellent in-vitro acitivity against the major respiratory pathogens- Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and group A b-haemolytic streptococci. It is also active against b-lactamase-producing strains of H. influenzae and M. catarrhalis. Cefetamet has marked activity against Neisseria gonorrhoeae and possesses a broad spectrum of activity against Enterobacteriaceae.

Pryzm
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Pryzm
Generic	Cefetamet Pivoxil Hydrochloride
Type	Tablet
Therapeutic Class	Third generation Cephalosporins
Manufacturer	Unichem Laboratories Ltd
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Cefetamet Pivoxil is used for the treatment of infections caused by sensitive microorganisms and in particular-

Otolaryngeal infections: Otitis media, Sinusitis, Tonsillo-pharyngitis
Infections of the lower respiratory tract: Tracheo-bronchitis, Bronchitis, Pneumonia
Infections of the complicated and uncomplicated urinary tract: Acute pyelonephritis, Acute gonorrhea, Urethritis.

Dosage

Pryzm dosage

Adults and children over 12 years: 500 mg twice daily.

Children under 12 years: Usual dosage is 10 mg/kg twice daily.

16-30 kg (approximately 3-9 years): 250 mg twice daily

31-40 kg (approximately 9-12 years): 375 mg twice daily

>40 kg (approximately over 12 years):500 mg twice daily

Uncomplicated gonorrhea, acute urethritis, uncomplicated cystitis: Single dose of 1500-2000 mg.

For better absorption Cefetamet Pivoxil should be taken one hour before or after a meal.

Side Effects

Most common gastrointestinal side effects may include diarrhea, nausea & vomiting. Like with other wider spectrum antibiotics, in the course of treatment with Cefetamet internal colonization from difficult Clostridium can be observed. In some cases, this microorganism or its toxin has been identified

Precaution

Cefetamet should be administered with caution to the patients who have previously manifested allergy phenomena or gastrointestinal problems. An anaphylactic reaction demands an emergency treatment. Like with other antibiotics, Cefetamet can cause the opportunistic development of non-sensitive germs (Candida, Enterococci, and difficult Clostridium); in such cases, a suitable therapy should be given. Discontinuation of the antibiotic helps to restore the normal microflora and the internal functions. In presence of difficult Clostridium cases, the treatment of choice is Vancomycin for oral use and the inhibiting drug of the peristalsis are contraindicated.

Interaction

The antacids and/or the H2-blockers do not alter the pharmacokinetic profile of Cefetamet; therefore, it can be administered in combination with these drugs. Concomitant administration with diuretic (e.g. Furosemide) does not reduce renal function.

Pregnancy & Breastfeeding use

The main preclinical studies carried out with Cefetamet have not evidenced teratogenic effects. There are no available data regarding safe use of Cefetamet during pregnancy & lactation. Therefore, it should be used during pregnancy & lactation only if the potential benefit justifies the potential risk to the fetus.

Contraindication

Cefetamet is contraindicated in patients with hypersensitivity to Cefetamet, any other cephalosporin or penicillins or any other ingredient of this formulation.

Special Warning

Renal insufficiency: In the patients with renal insufficiency, dosage modification is required.

Hepatic insufficiency: In patients with hepatic insufficiency dosage adjustment is not necessary.

Acute Overdose

In healthy volunteers, single doses of 4 gm have been administered without problems, except it causes transitory vertigo or dizziness. In case of prematurely diagnosed overdosage the gastric lavage can be useful. Then symptomatic treatment can be carried out.