Pyloryl

Pyloryl Uses, Dosage, Side Effects, Food Interaction and all others data.

Pyloryl is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.

Pyloryl is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

Trade Name Pyloryl
Generic Domperidone
Domperidone Other Names Domperidona, Domperidone, Domperidonum
Type Capsule
Formula C22H24ClN5O2
Weight Average: 425.911
Monoisotopic: 425.161852744
Protein binding

91%-93%

Groups Approved, Investigational, Vet approved
Therapeutic Class Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs
Manufacturer Mercury Health Care Pvt Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Pyloryl
Pyloryl

Uses

Stimulation of gut motility in-

  • Non-ulcer dyspepsia
  • Oesophageal reflux, reflux oesophagitis and gastritis
  • Diabetic gastroparesis
  • Functional dyspepsia
  • Speeding barium transit in follow through radiological studies

Prevention and symptomatic relief of acute nausea and vomiting from any cause including cytotoxic therapy, radiotherapy and antiparkinsonism therapy.

In the prophylactic treatment of migraine.

Pyloryl is also used to associated treatment for these conditions: Diabetic Gastroparesis, Dyspepsia, Erosive Esophagitis, Gastrointestinal Symptoms, Non-erosive Reflux Esophagitis Disease (NERD), Upper gastrointestinal motility disorders

How Pyloryl works

Pyloryl acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Pyloryl facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting

Dosage

Pyloryl dosage

Adults: 10 - 20 mg every 4 - 8 hours daily

Children: 0.2 - 0.4 mg/kg every 4 - 8 hours daily.

Pyloryl tablet and suspension should be taken 15 - 30 minutes before a meal. For acute nausea and vomiting, maximum period of treatment is 12 weeks.

Side Effects

Pyloryl may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.

Toxicity

Side effects include galactorrhea, gynecomastia, or menstrual irregularities.

Precaution

Pyloryl should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood brain barrier.

Interaction

Pyloryl may reduce the hypoprolactinaemic effect of bromocriptine. Anti-muscarinics and opioid analgesics may antagonize the action of Pyloryl on gastrointestinal function.

Food Interaction

  • Take before a meal. Take 15-30 minutes before meals.

Half Life

7 hours

Pregnancy & Breastfeeding use

Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy.

Use in lactation: Pyloryl may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.

Contraindication

Pyloryl is contraindicated to the patients who have hypersensitivity to this drug and in case of neonates.

Acute Overdose

Overdose has been reported primarily in infants and children. Symptoms of overdosage may include disorientation, somnolence and extrapyramidal reactions. There is no specific antidote to domperidone, but in the event of overdose, the administration of activated charcoal may be useful. Anticholinergics, antiparkinson drugs may be useful in controlling extrapyramidal reactions. The patient should be observed closely and supportive measures employed.

Storage Condition

Store in a cool dry place protected from light. Keep out of reach of children.

Innovators Monograph

You find simplified version here Pyloryl

Pyloryl contains Domperidone see full prescribing information from innovator Pyloryl Monograph, Pyloryl MSDS, Pyloryl FDA label

FAQ

What is Pyloryl used for?

Pyloryl help to stop feeling or being sick like as nausea or vomiting.It can also be used to treat stomach pain if you're having end of life care. Pyloryl is sometimes used to increase milk supply.

Is Pyloryl safe to take?

For most people, taking Pyloryl is safe.If you have heart problems or are taking other medicines, you should first check with your healthcare professional that this medicine is appropriate.

What are the side effects of Pyloryl?

Common side effects of Pyloryl are include:

  • swelling of the ankles/feet.
  • unusual tiredness.
  • mental/mood changes (e.g., nervousness, irritability)
  • hot flashes.
  • breast swelling/pain.
  • unusual leakage of milk from the breast.
  • changes in menstrual periods.
  • decreased sexual ability.

Is Pylorylsafe during pregnancy?

Pyloryl is not usually recommended in pregnancy.

Why Pyloryl is not safe in pregnancy?

Pyloryl is contraindicated for use in pregnant women and in women suspected of being pregnant, due to teratogenicity observed in reproductive toxicity studies.

Is Pyloryl safe during breastfeeding?

A very small amount of the Pyloryl you take can pass into your breast milk, but there is no record of harmful side effects in the baby from the mother taking Pyloryl.

Can I drink alcohol with Pyloryl?

It is best to avoid alcohol when taking Pyloryl. Drinking alcohol can make side effects worse, such as sleepiness or an irregular heartbeat.

How long does Pyloryl take to work?

Pyloryl often takes at least three or four days before you notice any effect. It usually takes about two weeks to get a maximum effect, but some find it takes even longer.

Can I take Pyloryl before bed?

Pyloryl is best taken 15 to 30 minutes before meals and id necessary at bedtime.

Is Pyloryl good for acid reflux?

It decreases postprandial reflux time and is therefore used to treat regurgitation and vomiting.

Can I take Pyloryl after eating?

Pyloryl is best taken about 15 to 30 minutes before meals, with a glass of water. If you take Pyloryl after a meal, it will still work, but it may take longer to have an effect.

Is Pyloryl good for gastritis?

Pyloryl has a good advantage in the treatment of reflux gastritis and is more effective than conventional treatment.Pyloryl is a kind of drug to strengthen gastric motility.

What does Pyloryl do to your body?

Pyloryl is a medicine that increases the movements or contractions of the stomach and bowel. Pyloryl is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.

Is Pyloryl safe for kidneys?

Pyloryl are not significantly renally cleared and can be used in CKD.

Does Pyloryl help anxiety?

Pyloryl is used to treat severe anxiety like as emotional state where you may sweat, tremble, feel anxious and have a fast heartbeat or agitation.

Does Pyloryl raise blood pressure?

Pyloryl increases blood pressure and heart rate without inducing nocturnal hypertension in apomorphine treated patients with idiopathic Parkinson's disease.

Is Pyloryl a narcotic?

Pyloryl is not a controlled substance e.g. sleeping pills, valium, narcotics.

Does Pyloryl cause depression?

Pyloryl can cause central nervous system side effects such as fatigue, irritability, or depression.

Can I take Pyloryl for a long time?

You should usually take Pyloryl for up to a week.Because Pyloryl can cause an irregular heartbeat if you take it for longer or at a high dose.

What happens when I stop taking Pyloryl?

Most women do not experience discomfort when stopping the medication, gradual weaning from the medication will help the mother's milk supply to adjust without frustrating the baby or causing her discomfort. It is very important to stop the Pyloryl slowly.

*** Taking medicines without doctor's advice can cause long-term problems.
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