Pyopen
Pyopen Uses, Dosage, Side Effects, Food Interaction and all others data.
Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.
Pyopen is a semisynthetic penicillin. Though carbenicillin provides substantial in vitro activity against a variety of both gram-positive and gram-negative microorganisms, the most important aspect of its profile is in its antipseudomonal and antiproteal activity. Because of the high urine levels obtained following administration, carbenicillin has demonstrated clinical efficacy in urinary infections due to susceptible strains of: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Pseudomonas species, Providencia rettgeri, Enterobacter species, and Enterococci (S. faecalis).
| Trade Name | Pyopen |
| Availability | Discontinued |
| Generic | Carbenicillin |
| Carbenicillin Other Names | Carbenicilina, Carbenicillin, Carbenicilline, Carbenicillinum, Carboxybenzylpenicillin, CBPC |
| Related Drugs | amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, ceftriaxone, levofloxacin, nitrofurantoin, Keflex |
| Type | Injection |
| Formula | C17H18N2O6S |
| Weight | Average: 378.4 Monoisotopic: 378.088557008 |
| Protein binding | 30 to 60% |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | Zydus Cadila Healthcare Ltd |
| Available Country | India, |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of acute and chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria due to susceptible strains of bacteria.
How Pyopen works
Free carbenicillin is the predominant pharmacologically active fraction of the salt. Pyopen exerts its antibacterial activity by interference with final cell wall synthesis of susceptible bacteria. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that carbenicillin interferes with an autolysin inhibitor.
Toxicity
Pyopen blood levels achievable are very low, and toxic reactions as a function of overdosage should not occur systematically. The oral LD50 in mice is 3,600 mg/kg, in rats 2,000 mg/kg, and in dogs is in excess of 500 mg/kg. The lethal human dose is not known. Symptoms of overdose include diarrhea, nausea, stomach upset, and vomiting.
Food Interaction
- Take on an empty stomach.
[Moderate] ADJUST DOSING INTERVAL: Certain penicillins may exhibit reduced gastrointestinal absorption in the presence of food.
The therapeutic effect of the antimicrobial may be reduced.
MANAGEMENT: The interacting penicillin should be administered one hour before or two hours after meals.
Penicillin V and amoxicillin are not affected by food and may be given without regard to meals.
Pyopen Hypertension interaction
[Moderate] Each 382 mg tablet of carbenicillin indanyl sodium contains approximately 23 mg (1 mEq) of sodium.
The sodium content should be considered in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.
Pyopen Drug Interaction
Unknown: acetaminophen, acetaminophen, aspirin, aspirin, rabeprazole, rabeprazole, risedronate, risedronate, fexofenadine, fexofenadine, alprazolam, alprazolam, cyclobenzaprine, cyclobenzaprine, naproxen, naproxen, divalproex sodium, divalproex sodium, penicillin v potassium, penicillin v potassium
Pyopen Disease Interaction
Major: colitisModerate: renal dysfunction, renal dysfunction, sodium, hemodialysis
Elimination Route
Rapidly absorbed from the small intestine following oral administration. Oral bioavailability is 30 to 40%.
Half Life
1 hour
Innovators Monograph
You find simplified version here Pyopen
