Pyrilamine

Pyrilamine Uses, Dosage, Side Effects, Food Interaction and all others data.

Pyrilamine is an ethylenediamine derived antihistamine with antimuscarinic and sedating properties.

Pyrilamine
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Pyrilamine
Generic	Mepyramine
Mepyramine Other Names	Mepiramina, Mepyramine, Pyranisamine, Pyrilamine
Type
Formula	C₁₇H₂₃N₃O
Weight	Average: 285.384 Monoisotopic: 285.184112373
Groups	Approved, Vet approved
Therapeutic Class	Topical Antihistamines
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Pruritic skin conditions

Pyrilamine is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Allergies, Atopic Dermatitis (AD), Common Cold, Insect Bites, Pollen Allergy, Rhinorrhoea, Urticaria, Itching skin

How Pyrilamine works

Pyrilamine is a histamine H1 receptor inverse agonist. It binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling. Pyrilamine competes with histamine for binding at H₁-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The sedative properties of Pyrilamine occur at the subcortical level of the CNS.

Dosage

Pyrilamine dosage

Apply 2% cream on affected areas.

Side Effects

Sedation; antimuscarinic effects, CNS depression and disturbances; occasionally, paradoxical CNS stimulation; psychomotor impairment; headache; palpitations and arrhythmias; convulsions, sweating, myalgia, paraesthesias, extrapyramidal symptoms, tremor, sleep and Gl disturbances, hypersensitivity reactions and blood dyscrasias; hypotension; hair loss; tinnitus.

Toxicity

The signs and symptoms that are produced after the acute overdosage of Pyrilamine include Convulsions, Coma, Ataxia, Hyperpyrexia, Tremor, Extrapyramidal effects, Excitement.

Precaution

Pregnancy; lactation; severe CV disorders; asthma; drowsiness; angle-closure glaucoma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction; renal and hepatic impairment; elderly; epilepsy. May affect ability to drive and operate machinery. Broken skin (topical).

Interaction

Increased effects with CNS depressants (e.g. alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and neuroleptics). Additive effects with other antimuscarinics (e.g. TCAs, atropine).