Quadropril

Quadropril Uses, Dosage, Side Effects, Food Interaction and all others data.

Quadropril is an ACE inhibitor antihypertensive drug used to treat hypertension. Quadropril is converted to the active spiraprilat after administration. ACE inhibitors are used primarily in treatment of hypertension and congestive heart failure.

Quadropril is an angiotensin-converting enzyme (ACE) inhibitor. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. By blocking ACE, spirapril decreases angiotensin II which is a vasoconstrictor and inducer of aldosterone. So by inhibiting the enzymes, aldosterone secreation is decreased (so less sodium is reabsorbed) and there is a decrease in vasoconstriction. Combined, this leades to a decrease in blood pressure.

Table Of contents

• Quadropril
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Quadropril
Generic	Spirapril
Spirapril Other Names	Espirapril, Spirapril, Spiraprilum
Type
Formula	C22H30N2O5S2
Weight	Average: 466.614 Monoisotopic: 466.15961346
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	Latvia, Lithuania, Russia
Last Updated:	September 19, 2023 at 7:00 am

Uses

Quadropril is an ACE inhibitor class drug used to treat hypertension.

How Quadropril works

Quadroprilat, the active metabolite of spirapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion. Quadroprilat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin.

Food Interaction

• Avoid hypertensive herbs (e.g. bayberry, blue cohosh, cayenne, ephedra, and licorice).
• Avoid potassium-containing products. Potassium products increase the risk of hyperkalemia.
• Limit salt intake. Salt may attenuate the antihypertensive effect.

Elimination Route

Bioavailability is 50% following oral administration.

Half Life

30 to 35 hours

Innovators Monograph

You find simplified version here Quadropril