Quazepam Sawai
Quazepam Sawai Uses, Dosage, Side Effects, Food Interaction and all others data.
Quazepam Sawai is a drug which is a benzodiazepine derivative. It induces impairment of motor function and has hypnotic properties. Quazepam Sawai is used to treat insomnia.
Quazepam Sawai is a benzodiazepine derivative. The main pharmacological action of quazepam is the enhancement of the neurotransmitter GABA at the GABAA receptor.
| Trade Name | Quazepam Sawai |
| Availability | Prescription only |
| Generic | Quazepam |
| Quazepam Other Names | Quazepam, Quazepamum |
| Related Drugs | amitriptyline, lorazepam, melatonin, zolpidem, diphenhydramine, Ativan |
| Type | |
| Formula | C17H11ClF4N2S |
| Weight | Average: 386.794 Monoisotopic: 386.026759579 |
| Groups | Approved, Illicit |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Japan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Quazepam Sawai is a long -acting benzodiazepine used to manage insomnia.
Used to treat insomnia.
Quazepam Sawai is also used to associated treatment for these conditions: Insomnia
Food Interaction
- Avoid alcohol. Ingesting alcohol may increase the drowsiness and CNS depression caused by quazepam.
[Moderate] GENERALLY AVOID: Acute alcohol ingestion may potentiate the CNS depression and other CNS effects of many benzodiazepines.
Tolerance may develop with chronic ethanol use.
The mechanism may be decreased clearance of the benzodiazepines because of CYP450 hepatic enzyme inhibition.
Also, it has been suggested that the cognitive deficits induced by benzodiazepines may be increased in patients who chronically consume large amounts of alcohol.
MONITOR: Grapefruit juice may increase the plasma concentrations of orally administered drugs that are substrates of the CYP450 3A4 isoenzyme.
However, the interaction seems to affect primarily those drugs that undergo significant presystemic metabolism by CYP450 3A4 (i.e., drugs with low oral bioavailability), presumably due to the fact that grapefruit juice inhibits intestinal rather than hepatic CYP450 3A4.
Because pharmacokinetic interactions involving grapefruit juice are often subject to a high degree of interpatient variability, the extent to which a given patient may be affected is difficult to predict.
MANAGEMENT: Patients should be advised to avoid alcohol during benzodiazepine therapy.
Patients who regularly consume grapefruit or grapefruit juice should be monitored for adverse effects and altered plasma concentrations of drugs that undergo significant presystemic metabolism by CYP450 3A4.
Grapefruit and grapefruit juice should be avoided if an interaction is suspected.
Orange juice is not expected to interact with these drugs.
Quazepam Sawai Drug Interaction
Major: acetaminophen / hydrocodoneModerate: aripiprazole, zolpidem, lorazepam, suvorexant, escitalopram, fluoxetine, ramelteon, diazepam, alprazolamUnknown: amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, amphetamine, bifidobacterium infantis, amoxicillin / clavulanate, ibuprofen, vortioxetine, ascorbic acid, cholecalciferol, lisdexamfetamine
Quazepam Sawai Disease Interaction
Major: acute alcohol intoxication, closed-angle glaucoma, drug dependence, renal/liver disease, respiratory depression, seizuresModerate: depression, obesity, paradoxical reactions, sleep disorders
Elimination Route
Bioavailability is 29-35% following oral administration.
Half Life
39 hours
Innovators Monograph
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