Quench
Quench Uses, Dosage, Side Effects, Food Interaction and all others data.
Silver sulfadiazine has broad antimicrobial activity. It is bactericidal for many Gram-negative and Gram-positive bacteria as well as being effective against yeast. After application of silver sulfadiazine cream onto the burn wound surface the compound acts a reservoir of silver ions. Silver ion exerts a bactericidal effect on bateria. Silver penetrates into cell of bacteria and binds to DNA, thereby inhibiting replications.
Silver sulfadiazine has broad antimicrobial activity. It is bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.
Trade Name | Quench |
Generic | Silver Sulfadiazine |
Silver Sulfadiazine Other Names | Silver sulfadiazinate, Silver sulfadiazine, Silver sulphadiazine, Sulfadiazine silver |
Weight | 1%w/w |
Type | Cream |
Formula | C10H9AgN4O2S |
Weight | Average: 357.137 Monoisotopic: 355.949714262 |
Groups | Approved, Vet approved |
Therapeutic Class | Topical Antibiotic preparations |
Manufacturer | Ferozsons Laboratoies Ltd, |
Available Country | Pakistan |
Last Updated: | September 19, 2023 at 7:00 am |
![Quench Quench](https://www.medicinesfaq.com/media/png/quench.png)
Uses
Prophylaxis and treatment of infection in burn wounds-
As an adjunct to short-term treatment of infection in
- Leg ulcers
- Pressure sores
As an adjunct to prophylaxis of infection in
- Skin graft donor sites
- Extensive abrasions
Conservative management of Finger-tip injuries
Silver Sulphadiazine is a local chemotherapeutic agent for prevention and treatment of burn wound infections. Silver Sulphadiazine disintegrates in the burn wound, thereby causing a slow and sustained release of silver ions. Silver ions bind to bacterial Deoxyribonucleic acid (DNA), thus inhibiting the growth and multiplication of bacterial cells without affecting the cells of the skin and subcutaneous tissue. Quench cream has a broad antibacterial spectrum including virtually all microbial species likely to infect the burn wound: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, strains of Proteus and Klebsiella. It is also an effective agent against Candida albicans and other fungi. Quench penetrates into the necrotic tissue and exudate. This effect is very important in view of the fact that systemic antibiotics are not effective against the bacterial flora of vascular burn necrosis.
Quench is also used to associated treatment for these conditions: Wound Infections
How Quench works
Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. A specific mechanism of action has not been determined, but silver sulfadiazine's effectiveness may possibly be from a synergistic interaction, or the action of each component. Silver is a biocide, which binds to a broad range of targets. Silver ions bind to nucleophilic amino acids, as well as sulfhydryl, amino, imidazole, phosphate, and carboxyl groups in proteins, causing protein denaturation and enzyme inhibition. Silver binds to surface membranes and proteins, causing proton leaks in the membrane, leading to cell death. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Dosage
Quench dosage
Burns: Keep the burn wound in clean condition and apply Burnsil over the affected area to a depth of 3 to 5 mm. This application is best achieved with a sterile gloved hand and/or a sterile spatula. Where necessary, the cream should be re-applied to any area from which it has been removed by patient activity. In burns, Burnsil should be re-applied at least every 24 hours, or more frequently if the volume of exudate is large.
Hand burns: Apply Burnsil to the burn area and enclose with a clean plastic bag or glove upto wrist. The patient should be encouraged to move the hand and fingers. The dressing should be changed when an excessive amount of exudate has accumulated in the bag.
Leg ulcers/pressure sores: The cavity of ulcer should be filled with Burnsil to a depth of at least 3-5 mm. As Burnsil can cause maceration of normal skin on prolonged contact, care should be taken to prevent spread on the non-ulcerated areas. Application of Burnsil should be followed by an absorbed pad or gauze dressing, with further application of pressure bandaging as appropriate for the ulcer. The dressings should normally be changed daily but for wounds which are less exudative, less frequent changes (every 48 hours) may be acceptable. Cleanings and debriding should be performed before application of Burnsil. Burnsil is not recommended for use in leg or pressure ulcer that is very exudative.
Fingertip injuries: Haemostasis of the injury should be achieved prior to the application of a 3-5 mm layer of Burnsil . A conventional finger dressing may be used. Alternatively waterproof adhesive tape can be used on finger covered by a plastic or surgical glove. Dressings should be changed every 2-3 days.
Side Effects
In prolonged treatment of burn wounds involving extensive areas of the body the serum Sulphonamide concentrations may approach the levels equal to those in systemic treatment.
Toxicity
Acute oral toxicity (LD50) in rat is 10001 mg/kg.
Precaution
Precautions: Caution is required in the presence of hypersensitivity to Sulphonamides because of possible allergic reactions, in patients with inborn glucose-6-phosphate dehydrogenase deficiency, as haemolysis may occur after the application of the cream to the large body surface area; as well as in the presence of hepatic and renal dysfunction.When treatment with Burnsil cream involves prolonged administration or large burn surfaces, the white blood cell count should be monitored, as leukopenia may occur.
Warning: Elevation of body temperature occurring in children during the first days of treatment is unrelated to Burnsil administration and should not lead to the discontinuation of therapy.
Food Interaction
No interactions found.Elimination Route
Very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally an issue.
Pregnancy & Breastfeeding use
As Sulphonamide therapy is known to increase the possibility of kernicterus, Silver Sulphadiazine 1% cream should not be used on pregnant women approaching or at term.
Contraindication
The use of Burnsil is contraindicated in premature infants and neonates because of possible kernicterus. It should not be used in pregnancy, except in cases when the potentially life-saving benefits of the medication outweigh possible hazards to the foetus
Special Warning
Infant: The cream should not be used on premature infants, or on newborn infants during the first 2 months of life.
Innovators Monograph
You find simplified version here Quench
Quench contains Silver Sulfadiazine see full prescribing information from innovator Quench Monograph, Quench MSDS, Quench FDA label
FAQ
What is Quench used for?
Quench is used to prevent and treat infections of second- and third-degree burns. It kills a wide variety of bacteria.
How safe is Quench?
Although the risk of serious side effects is low when Quench is applied to the skin, side effects can occur if the medicine is absorbed into your bloodstream.
How does Quench work?
Quench works by stopping the growth of bacteria that may infect an open wound.
What are the common side effects of Quench?
The common side effects of Quench are include:
- Back, leg, or stomach pains
- blistering, peeling, or loosening of the skin
- blue-green to black skin discoloration
- dark urine
- fever with or without chills
- general body swelling
- increased sensitivity of the skin to sunlight, especially in patients with burns on large areas
- intense itching of burn wounds
- light-colored stools
- lower back or side pain
- nausea or vomiting
- pinpoint red spots on the skin
- red skin lesions, often with a purple center
- red, swollen skin
- skin rash
- sores, ulcers, or white spots in the mouth or on the lips
- swollen or painful glands
- unusual bleeding or bruising
- unusual tiredness or weakness
- upper right abdominal or stomach pain
- yellow eyes and skin
Is Quench safe during pregnancy?
Quench topical is not expected to harm an unborn baby. However, this medicine can cause serious medical problems in a newborn and should not be used during late pregnancy.
Is Quench safe during breastfeeding?
Quench is not known whether Quench topical passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
How long does Quench take to work?
Quench take to work within 3 to 5 days.
When should I stop using Quench?
To help clear up your skin or burn infection completely, keep using this medicine for the full time of treatment. You should keep using this medicine until the burned area has healed or is ready for skin grafting.
Is Quench an antibiotic?
The class of Quench known as sulfa antibiotics.
Does Quench heal burns faster?
This study finds faster complete healing and a higher percentage of infection resolution in honey-treated wounds.
Should Quench be taken with food?
You should drink plenty of fluids and take Quench on an empty stomach.
Is Quench safe for babies?
Quench topical is not expected to harm an unborn baby.
Is Quench good for acne?
Quench appears to be particularly suitable for use as an acne therapy option due to the low risk of bacterial resistance.
What happens if I use too much Quench?
Your burn wounds should be kept covered with Quench cream at all times. An overdose of Quench topical is not expected to be dangerous. Seek emergency medical attention.
Does Quench help with burn pain?
Quench used to prevent and treat wound infections in patients with second- and third-degree burns. Patients with severe burns or burns over a large area of the body must be treated in a hospital.
How do I take Quench?
Take Quench exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. The tablets should be taken with a full glass of water. Continue to take Quench even if you feel well.
What happens if I miss a dose of?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What should I avoid while taking Quench?
Avoid exposure to sunlight or tanning beds.Quench can make you sunburn more easily. Wear protective clothing and use sunscreen when you are outdoors.
Can Quench be used for bed sores?
Quench should be used for up to two weeks for clean ulcers that are not healing properly after two to four weeks of optimal wound care.