R-Warfarin Alcohol
R-Warfarin Alcohol Uses, Dosage, Side Effects, Food Interaction and all others data.
Warfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared by different pathways. S-warfarin is 2-5 times more potent than the R-isomer in producing an anticoagulant response.
Trade Name | R-Warfarin Alcohol |
Generic | (R)-warfarin |
(R)-warfarin Other Names | R-warfarin, R,R-Warfarin alcohol |
Type | |
Formula | C19H16O4 |
Weight | Average: 308.3279 Monoisotopic: 308.104859 |
Groups | Experimental |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Food Interaction
- Avoid drastic dietary changes.
- Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.
- Ensure consistent Vitamin K intake.
- Exercise caution with grapefruit products. Grapefruit inhibits CYP3A4 metabolism, which may increase the serum levels of R-warfarin.
- Exercise caution with St. John's Wort. This herb induces CYP3A4 metabolism, which may reduce the serum levels of R-warfarin.
Volume of Distribution
The volume of distribution was 10.9L (95% confidence interval 8.63, 13.2), according to a study by Lane et al.
Clearance
0.125L/h, (95% confidence interval 0.115, 0.135) in a 70kg individual aged 69.8yr with the wild type CYP2C19 and CYP3A4 genotypes.
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