Racetril 10 mg/sachet Oral Powder Uses, Dosage, Side Effects and more

Racetril 10 mg/sachet Oral Powder increases the availability of endogenous opioids (enkephalins) by inhibiting the membrane-bound enkephalinase. The enkephalins in turn mediate their effect through δ receptor ( delta opioid receptor) activation that induces a selective increase in Cl absorption by inhibiting adenylate cyclase.

Onset: 30 min (plasma enkephalinase inhibition).

Trade Name	Racetril 10 mg/sachet Oral Powder
Generic	Racecadotril
Racecadotril Other Names	Racecadotril, Racecadotrilo
Weight	10 mg/sachet
Type	Oral Powder
Formula	C21H23NO4S
Weight	Average: 385.48 Monoisotopic: 385.134779399
Groups	Investigational
Therapeutic Class	Anti-diarrhoeal
Manufacturer	Incepta Pharmaceuticals Ltd.
Available Country	Bangladesh
Last Updated:	January 7, 2025 at 1:49 am

Uses

Racetril 10 mg/sachet Oral Powder is used for the symptomatic treatment of acute diarrhea.

Racetril 10 mg/sachet Oral Powder is a pure intestinal antisecretory active substance. It decreases the intestinal hypersecretion of water and electrolytes induced by cholera toxin or inflammation and does not have effects on basal secretory activity.

Following oral administration, Racetril 10 mg/sachet Oral Powder is rapidly absorbed and then hydrolysed to thiorphan, which is an inhibitor of enkephalinase, a cell membrane peptidase located in various tissues, notably the epithelium of the small intestine. This enzyme contributes both to the hydrolysis of exogenous peptides and to the breakdown of endogenous peptides such as enkephalins. Racetril 10 mg/sachet Oral Powder protects enkephalins from enzymatic degradation thereby prolonging their action at enkephalinergic synapses in the small intestine and reducing hypersecretion. Racetril 10 mg/sachet Oral Powder exerts rapid antidiarrhoeal action, without modifying the duration of intestinal transit.

Racetril 10 mg/sachet Oral Powder is also used to associated treatment for these conditions: Acute Diarrhoea, Diarrhoea

Dosage

Racetril 10 mg/sachet Oral Powder dosage

Adults: One capsule initially, regardless of the time of day. Then one capsule three times daily preferably before the main meals.

Children (from 3 months of age): Racetril 10 mg/sachet Oral Powder granules should be administered together with oral rehydration. The recommended dose is determined according to body weight: 1.5 mg/kg per administration, three times daily.

• Infants less than 9 kg: one 10 mg sachet 3 times daily.
• Infants from 9 kg to 13 kg: two 10 mg sachets 3 times daily.
• Children from 13 kg to 27 kg: one 30mg sachet 3 times daily.
• Children of more than 27 kg: two 30mg sachets 3 times daily.

Side Effects

Headache, erythema multiforme, urticaria, angioedema may be seen.

Precaution

The administration of Racetril 10 mg/sachet Oral Powder does not modify the usual rehydration regimens. The presence of bloody stools and fever may indicate the presence of invasive bacteria as a reason for diarrhea or the presence of other severe disease. Racetril 10 mg/sachet Oral Powder has not been tested in antibiotic-associated diarrhea and should therefore not be administered under these conditions. Caution should be taken in patients with renal or liver impairment.

Interaction

No drug interactions found. Joint treatment with Racetril 10 mg/sachet Oral Powder and Loperamide or Nifuroxazide does not modify the kinetics of Racetril 10 mg/sachet Oral Powder.

Pregnancy & Breastfeeding use

Due to a lack of clinical data, Racetril 10 mg/sachet Oral Powder should not be administered to pregnant or breastfeeding women.

Contraindication

Hypersensitivity to Racetril 10 mg/sachet Oral Powder, or to any of the excipients.

Acute Overdose

No cases of overdose have been reported. In adults, single doses above 2 g which is equivalent to 20 times the therapeutic dose, have been administered, and no harmful effects have been described.

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