Раксар
Раксар Uses, Dosage, Side Effects, Food Interaction and all others data.
Раксар is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States.
Раксар has in vitro activity against a wide range of gram-positive and gram-negative aerobic microorganisms, as well as some atypical microorganisms.
Trade Name | Раксар |
Availability | Discontinued |
Generic | Grepafloxacin |
Grepafloxacin Other Names | Grepafloxacin |
Related Drugs | amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin |
Type | |
Formula | C19H22FN3O3 |
Weight | Average: 359.3947 Monoisotopic: 359.16451979 |
Protein binding | 50% |
Groups | Approved, Investigational, Withdrawn |
Therapeutic Class | |
Manufacturer | |
Available Country | Russia |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Раксар is a fluoroquinolone antibiotic used to treat various gram positive and gram negative bacterial infections.
For treatment of adults with mild to moderate infections caused by susceptible strains of Haemophilus influenzae, Streptococcus pneumoniae, or Moraxella catarrhalis.
How Раксар works
Раксар exerts its antibacterial activity by inhibiting bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, essential enzymes for duplication, transcription, and repair of bacterial DNA.
Toxicity
Withdrawn from the US market in 1999 due to associations with QTc prolongation and adverse cardiovascular events.
Food Interaction
- Avoid caffeine.
- Drink plenty of fluids.
- Take with or without food. The absorption is unaffected by food.
Раксар multivitamins interaction
[Moderate] ADJUST DOSING INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics.
Absorption may also be reduced by sucralfate, which contains aluminum, as well as other polyvalent cations such as iron and zinc.
The mechanism is chelation of quinolones by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract.
The bioavailability of ciprofloxacin has been reported to decrease by as much as 90% when administered with antacids containing aluminum or magnesium hydroxide.
When coadministration cannot be avoided, quinolone antibiotics should be dosed either 2 to 4 hours before or 4 to 6 hours after polyvalent cation-containing products to minimize the potential for interaction.
When coadministered with Suprep Bowel Prep (magnesium Please consult individual product labeling for specific recommendations.
Раксар Drug Interaction
Major: insulin glargine, insulin glargineModerate: aspirin, aspirin, atorvastatin, atorvastatin, acarbose, acarboseUnknown: carvedilol, carvedilol, hydrochlorothiazide, hydrochlorothiazide, simethicone, simethicone, finasteride, finasteride, clobetasol topical, clobetasol topical, cyanocobalamin, cyanocobalamin
Раксар Disease Interaction
Major: CNS disorders, myasthenia gravis, peripheral neuropathy, tendonitis
Elimination Route
Rapidly and extensively absorbed following oral administration. The absolute bioavailability is approximately 70%.
Half Life
15 ± 3 hours
Innovators Monograph
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