Раксар

Раксар Uses, Dosage, Side Effects, Food Interaction and all others data.

Раксар is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States.

Раксар has in vitro activity against a wide range of gram-positive and gram-negative aerobic microorganisms, as well as some atypical microorganisms.

Trade Name Раксар
Availability Discontinued
Generic Grepafloxacin
Grepafloxacin Other Names Grepafloxacin
Related Drugs amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin
Type
Formula C19H22FN3O3
Weight Average: 359.3947
Monoisotopic: 359.16451979
Protein binding

50%

Groups Approved, Investigational, Withdrawn
Therapeutic Class
Manufacturer
Available Country Russia
Last Updated: September 19, 2023 at 7:00 am
Раксар
Раксар

Uses

Раксар is a fluoroquinolone antibiotic used to treat various gram positive and gram negative bacterial infections.

For treatment of adults with mild to moderate infections caused by susceptible strains of Haemophilus influenzae, Streptococcus pneumoniae, or Moraxella catarrhalis.

How Раксар works

Раксар exerts its antibacterial activity by inhibiting bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, essential enzymes for duplication, transcription, and repair of bacterial DNA.

Toxicity

Withdrawn from the US market in 1999 due to associations with QTc prolongation and adverse cardiovascular events.

Food Interaction

  • Avoid caffeine.
  • Drink plenty of fluids.
  • Take with or without food. The absorption is unaffected by food.

Раксар multivitamins interaction

[Moderate] ADJUST DOSING INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics.

Absorption may also be reduced by sucralfate, which contains aluminum, as well as other polyvalent cations such as iron and zinc.

The mechanism is chelation of quinolones by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract.

The bioavailability of ciprofloxacin has been reported to decrease by as much as 90% when administered with antacids containing aluminum or magnesium hydroxide.

When coadministration cannot be avoided, quinolone antibiotics should be dosed either 2 to 4 hours before or 4 to 6 hours after polyvalent cation-containing products to minimize the potential for interaction.

When coadministered with Suprep Bowel Prep (magnesium

Please consult individual product labeling for specific recommendations.

Elimination Route

Rapidly and extensively absorbed following oral administration. The absolute bioavailability is approximately 70%.

Half Life

15 ± 3 hours

Innovators Monograph

You find simplified version here Раксар

*** Taking medicines without doctor's advice can cause long-term problems.
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