Rancil
Rancil Uses, Dosage, Side Effects, Food Interaction and all others data.
Rancil acts on the L-type calcium channels of blood vessels by blocking the incoming calcium and suppressing the contraction of blood vessels, thereby reducing blood pressure. Rancil also works on the N-type calcium channel located at the end of the sympathetic nerve, inhibiting the emission of norepinephrine and suppressing the increase in stress blood pressure.
Administration of cilnidipine has been shown to present an antisympathetic profile in vitro and in vivo. It decreases blood pressure safely and effectively without excessive blood pressure reduction or tachycardia.
| Trade Name | Rancil |
| Generic | Cilnidipine |
| Cilnidipine Other Names | Cilnidipine |
| Type | Tablet |
| Formula | C27H28N2O7 |
| Weight | Average: 492.528 Monoisotopic: 492.18965125 |
| Protein binding | Cilnidipine presents a very high protein binding that represents to even 98% of the administered dose. |
| Groups | Investigational |
| Therapeutic Class | Calcium-channel blockers |
| Manufacturer | Ranbaxy Laboratories (sun Pharma) |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Rancil is used for the management of hypertension for end-organ protection. It is reported to be useful in elderly patients and in those with diabetes and albuminuria. Rancil has been increasingly used in patients with chronic kidney disease.
Hypertension is the term used to describe the presence of high blood pressure. The blood pressure is generated by the force of the blood pumped from the heart against the blood vessels. Thus hypertension is caused when there is too much pressure on the blood vessels and this effect can damage the blood vessel
Rancil is also used to associated treatment for these conditions: High Blood Pressure (Hypertension)
How Rancil works
Rancil acts on the L-type calcium channels of blood vessels by blocking the incoming calcium and suppressing the contraction of blood vessels, thereby reducing blood pressure. Rancil also works on the N-type calcium channel located at the end of the sympathetic nerve, inhibiting the emission of norepinephrine and suppressing the increase in stress blood pressure.
Dosage
Rancil dosage
5-10 mg once daily, increase to 20 mg once daily if necessary.
Side Effects
Dizziness; flushing; headache; hypotension; peripheral oedema; tachycardia; palpitations; GI disturbances; increased micturition frequency; lethargy; eye pain; depression; ischaemic chest pain; cerebral or myocardial ischaemia; transient blindness; rashes; fever; abnormal liver function; gingival hyperplasia; myalgia; tremor; impotence.
Toxicity
The percentage of reports of cilnidipine that express drug toxicity reported as side effects are 5.26%.
Precaution
Hypotension, poor cardiac reserve, heart failure. Sudden withdrawal may exacerbate angina. Discontinue in patients who experience ischemic pain following administration. Pregnancy, lactation.
Interaction
Other antihypertensives; aldesleukin; antipsychotics that cause hypotension; may modify insulin and glucose responses; quinidine; carbamazepine; phenytoin; rifampicin; cimetidine; erythromycin.
Volume of Distribution
Drugs on the group of dihydropyridines such as cilnidipine tend to have a large volume of distribution.
Elimination Route
Rancil presents a very rapid absorption with a maximum peaked concentration after 2 hours. Its distribution tends to be higher in the liver as well as in kidneys, plasma and other tissues. Rancil does not present a high accumulation in the tissue after repeated oral administration.
Rancil is reported to present very low bioavailability determined to be approximately 13%. This low bioavailability is suggested to be due to its low aqueous solubility and high permeability. Hence, efforts have been made in order to find an innovative formulation that can significantly improve the bioavailability of this drug. One of these formulations corresponds to the generation of polymeric nanoparticles which enhance the bioavailability by 2.5-3-fold.
Half Life
The half-life of the hypotensive effect for cilnidipine is of about 20.4 min.
Elimination Route
Rancil gets eliminated through the urine in a proportion of 20% of the administered dose and 80% is eliminated by the feces.
Pregnancy & Breastfeeding use
No specific information about USFDA pregnancy category. Caution should be exercised during Rancil use in pregnancy. Nursing mothers should consult a physician before taking Rancil.
Contraindication
Cardiogenic shock; recent MI or acute unstable angina; severe aortic stenosis.
Innovators Monograph
You find simplified version here Rancil
Rancil contains Cilnidipine see full prescribing information from innovator Rancil Monograph, Rancil MSDS, Rancil FDA label
FAQ
What is the use of Rancil?
Rancil used to treat high blood pressure (hypertension). It belongs to a class of medicines known as a calcium channel blocker which helps to lower blood pressure. This helps prevent heart attacks and strokes. It may also be prescribed to prevent angina (heart-related chest pain). Rancil is approved for use in Japan, China, India, Nepal, Korea, and some European countries to treat hypertension.
Is Rancil safe?
It has been reported that once-daily administration of cilnidipine resulted in a safe and more effective BP decrease in essential hypertension without excessive BP reduction or reflex tachycardia than similar administration than once-daily administration of nifedipine (14) or nisoldipine (15).
How does Rancil work?
Rancil work by decreases blood pressure. Due to its blocking action at the N-type and L-type calcium channel, cilnidipine dilates both arterioles and venules, reducing the pressure in the capillary bed.
What are the common side effects of Rancil?
The side effects could be severe dizziness, fast heartbeat, and swelling of face, lips, tongue, eyelids, hands and feet.
Is Rancil safe during pregnancy?
Rancil is not rendered 'safe' for use during pregnancy. Hence, it should not usually be used during pregnancy because other relatively safer alternatives to control blood pressure are available.
Is Rancil safe during breastfeeding?
Rancil passes into breast milk in amounts that are probably too small to be harmful to a nursing infant. It's generally considered safe to breastfeed while taking Rancil. No adverse effects have been reported in breastfed babies.
Can I drink alcohol with Rancil ?
Rancil may cause a decrease in blood pressure so avoid alcohol while using this medicine.
Can I drive after taking Rancil?
Consumption of Rancil may cause dizziness. Avoid activities like driving while on this medication.
When should be taken of Rancil?
Rancil Tablet can be taken anytime of the day. Usually, it is advised to be taken in the morning, but your doctor may advise to take it in the evening as well. You should take it at the same time each day so that you remember to take it and consistent levels of medicine are maintained in the body.
How Rancil should be taken?
Rancil comes in the form of a tablet and to be taken orally either once daily or as directed by the physician.
Can I take Rancil on an empty stomach?
This Rancil can be taken either before or after meals.
How long does Rancil take to work?
Rancil starts to work on the day you start taking it, but it may take a couple of weeks fully take effect. If you're taking nifedipine for high blood pressure, you may not have any symptoms. In this case, you may not feel any different when you take it.
How long does Rancil stay in my system?
The elimination half-life of Rancil is approximately two hours.
Can I take Rancil for a long time?
Usually, treatment with Rancil is long term, even for the rest of your life.
Who should not take Rancil?
You should not use Rancil if you have severe coronary artery disease, or if you have had a heart attack within the past 2 weeks.
What happen If I stop taking Rancil?
Talk to your doctor if you want to stop taking Rancil. Stopping Rancil may cause your blood pressure to rise – and this may increase your risk of heart attack and stroke. If you're bothered by side effects, your doctor may be able to prescribe you a different medicine.
What happen If I overdose on Rancil?
Taking too much of this drug may cause severe side effects such as very low blood pressure (hypotension), a dangerously slow heart rate (bradycardia), heart failure, trouble breathing, extreme tiredness, dizziness, or very low blood sugar that could even lead to a coma. If you take too much nebivolol, call your doctor or go to the nearest hospital emergency department right away.
What happen If I missed Rancil?
If you forget to take your dose, take it as soon as you remember, unless you remember just a few hours before the time for your next dose. Then only take one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.
Can Rancil affects my heart ?
Rancil may inhibit increases in heart rate and QT interval. Rancil may have beneficial effects in reducing cardiovascular events, resulting from increased sympathetic nerve activity and lethal arrhythmias in hemodialysis patients.
Can Rancil affect my kidneys?
Rancil effectively reduces the low- grade albuminuria in hypertensive CKD patient but main adverse effect of this drug induces the ankle edema, pedal edema, and peripheral edema.
