Ranirestat
Ranirestat Uses, Dosage, Side Effects, Food Interaction and all others data.
Ranirestat is a structurally novel and stereospecifically potent aldose reductase (AKR1B; EC 1.1.1.21) inhibitor, which contains a succinimide ring that undergoes ring-opening at physiological pH levels. It has been used in trials studying the treatment of Mild to Moderate Diabetic Sensorimotor Polyneuropathy.
| Trade Name | Ranirestat |
| Generic | Ranirestat |
| Ranirestat Other Names | Ranirestat |
| Type | |
| Formula | C17H11BrFN3O4 |
| Weight | Average: 420.189 Monoisotopic: 418.991696707 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in neuropathy (diabetic).
How Ranirestat works
Ranirestat alleviates diabetic neuropathy, a complication of diabetes, by inhibiting aldose reductase and thereby inhibiting the accumulation of intracellular sorbitol that causes diabetic neuropathy. This drug has a stronger inhibitory effect and is longer acting compared to other drugs in this therapeutic area. Ranirestat showed good penetration into the nerve tissue, resulting in dose-dependent inhibition of intraneural accumulation of sorbitol and fructose in a clinical study.
Innovators Monograph
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