Recombinant Interleukin-11
Recombinant Interleukin-11 Uses, Dosage, Side Effects, Food Interaction and all others data.
Recombinant Interleukin-11, the active ingredient in Neumega®, is recombinant Interleukin-11 (IL-11), which is produced in Escherichia coli (E. coli) by recombinant DNA technology. With a molecular mass of approximately 19,000 daltons, the non-glycosylated protein is 177 amino acids in length in comparison to the natural IL-11, which is 178 amino acid long. However, it displays comparable biological activity compared to the natural IL-11 in vitro and in vivo. Recombinant Interleukin-11 works by stimulating megakaryocytopoiesis and thrombopoiesis. In mice and nonhuman primate studies of animals with moderate and severe myelosuppression, in addition to compromised hematopoiesis, oprelvekin was shown to potently induce thrombopoiesis and improve platelet nadirs and accelerated platelet recoveries compared to controls. In animal studies, oprelvekin was also shown to regulate intestinal epithelium growth by enhancing healing of gastrointestinal lesions, inhibit adiopegenesis and macrophageal released pro-inflammatory cytokines, and induce acute phase protein synthesis.
Recombinant Interleukin-11 promotes hematopoiesis by stimulating megakaryocytopoiesis and thrombopoiesis. It is used in adult patients with nonmyeloid malignancies to prevent severe thrombocytopenia and reduce the need for platelet transfusions following therapies that cause myelosuppression. Its use is prioritized in patients who are at an elevated risk for developing severe thrombocytopenia. In clinical trials, oprelvekin has shown potent thrombopoietic activity in individuals with compromised hematopoiesis.
| Trade Name | Recombinant Interleukin-11 |
| Availability | Discontinued |
| Generic | Oprelvekin |
| Oprelvekin Other Names | IL-11, Interleukin 11, Interleukin-11, Oprelvekin, Recombinant interleukin-11 |
| Related Drugs | Neumega, Refludan |
| Type | |
| Formula | C854H1411N253O235S2 |
| Weight | 19047.2 Da |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Recombinant Interleukin-11 is a form of recombinant interleukin-11 used to stimulate production of megakaryocytes and platelets in patients with or at risk of thrombocytopenia after chemotherapy.
Indicated for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusions following myelosuppressive chemotherapy in adult patients with nonmyeloid malignancies who are at high risk of severe thrombocytopenia.[Label]
Recombinant Interleukin-11 is also used to associated treatment for these conditions: Thrombocytopenia
How Recombinant Interleukin-11 works
Recombinant Interleukin-11 binds to the interleukin 11 receptor which leads to a cascade of signal transduction events. Its pharmacological action mimics the biological activity of endogenous IL-11, which is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.
Recombinant Interleukin-11 Disease Interaction
Major: fluid retentionModerate: arrhythmias, papilledema, renal impairment
Elimination Route
Absolute bioavailability is over 80%.
Half Life
6.9 +/- 1.7 hrs
Elimination Route
The kidney is the primary route of elimination. The amount of intact Neumega in urine was low, indicating that the molecule was metabolized before excretion.
Innovators Monograph
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