Regurnil
Regurnil Uses, Dosage, Side Effects, Food Interaction and all others data.
fructose is frequently derived from sugar cane, sugar beets, and corn. Crystalline fructose is the monosaccharide, dried, ground, and of high purity. High fructose corn syrup (HFCS) is a mixture of glucose and fructose as monosaccharides. Sucrose is a compound with one molecule of glucose covalently linked to one molecule of fructose. All forms of fructose, including fruits and juices, are commonly added to foods and drinks for palatability and taste enhancement, and for browning of some foods, such as baked goods.
Phosphoric Acid is a colorless, odorless phosphorus-containing inorganic acid. Phosphoric acid is a sequestering agent which binds many divalent cations, including Fe++, Cu++, Ca++, and Mg++.
Transport of phosphate from the gut lumen is an active, energy-dependent process that is modified by several factors. ... Vitamin D stimulates phosphate absorption, an effect reported to precede its action on calcium ion transport.
| Trade Name | Regurnil |
| Generic | Fructose + Glucose + Phosphoric Acid |
| Type | Syrup |
| Therapeutic Class | |
| Manufacturer | Unicure Remedies Pvt Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Fructose is used intravenously as a carbohydrate nutrient. It is converted to liver glycogen and metabolized more rapidly than dextrose without requiring insulin and thus may be used in diabetic patients. Fructose is used for patients requiring fluid replacement and caloric feeding. It is better "nitrogen sparer" than glucose.
Phosphoric acid is an ingredient used for electrolyte replenishment and total parenteral nutrition (TPN) therapy, and for the relief of upset stomach associated with nausea.
Phosphoric acid is used in dentistry and orthodontics as an etching solution, to clean and roughen the surfaces of teeth where dental appliances or fillings will be placed.
Regurnil is also used to associated treatment for these conditions: Nausea, Upset stomachTotal parenteral nutrition therapy
How Regurnil works
Phosphate supplementation of the diet of rodents has been shown to lead to reduction in the incidence of dental caries and different phosphates have different powers in reducing the cariogenic potential of the carbohydrates in a diet. Phosphate supplements seem to exert their cariostatic effect on the tooth surface either directly during eating or by excretion in the saliva.
Dosage
Regurnil dosage
The volume and rate of infusion of fructose IV solution will depend upon the requirements of the patient and the judgement of attending physician. But the rate of infusion of fructose should not exceed 0.5-1 gm/kg body weight per hour.The usual recommended flow rate for adult is 30-75 drops per minute infused intravenously.
Side Effects
Intravenous administration of fructose may cause lactic acidosis and hyperuricemia.The rapid infusion of fructose results in facial flushing, abdominal pain and sweating.
Toxicity
Man: LDLo, route unreported at 220mg/kg Rabbit: LD 50, Route: Skin, Reported dose: 2740 mg /kg, Effects: Behavioral : somnolence ( general depressed activity), Excitement Rat: LC50, Route: inhalation, Reported dose: >850 mg/m3/1h Rat: LD50, Route: oral, Reported dose: 1530 mg/kg, Effects: Kidney, ureter and bladder hematuria, Behavioral: somnolence (general depressed activity)
Precaution
Fructose should not be given to patients with hereditary fructose intolerance. It should be given with caution to patients with impaired kidney function or severe liver damage.
Infusion of fluid should be immediately discontinued if rigor arises for any reason during the process. Do not use if the solution is cloudy, contains particles, or after expiry date.
Volume of Distribution
Absorbed phosphoric acid is distributed widely in the body as phosphate. Increased serum phosphate concentrations have been reported rarely after phosphoric acid ingestion
Elimination Route
Ortho phosphate is absorbed from, and to a limited extent secreted into, the gastrointestinal tract.
Half Life
In infants with normal renal function the serum half-life of phosphate following single oral or rectal overdose is 5-11 hours
Clearance
Absorbed phosphate is filtered at the glomerulus and partially reabsorbed, with phosphate clearance 80 per cent of creatinine clearance.
Elimination Route
In adults, about two thirds of the ingested phosphate is absorbed, and that which is absorbed is almost entirely excreted into the urine.
Contraindication
Fructose is contraindicated in certain inborn errors of fructose metabolism, methyl alcohol poisoning, hyperuricemia, liver failure, and lactic acidosis.
Storage Condition
This should be stored at controlled room temperature
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