Rejoin-D Tablet 750 mg+50 mg

Rejoin-D Tablet 750 mg+50 mg Uses, Dosage, Side Effects, Food Interaction and all others data.

Glucosamine: Glucosamine (2-amino-2-deoxy-alpha-D-glucose) is a natural amino sugar, produced by the body and found in certain foods. It is the most fundamental building block required for biosynthesis of glycosaminoglycans (GAGs) like Hyaluronic Acid, Keratan Sulfate and Chondroitin Sulfate. GAGs binds with protein and form proteoglycans, the essential building block of articular cartilage. When cartilage in a joint deteriorates, Osteoarthritis develops. It also helps to form ligaments, tendon, nails and various other connective tissues. When we take artificially synthesized Glucosamine Sulfate supplement, it increases Glucosamine level in the body, thus facilitates production and repair of cartilage. Glucosamine also activates chondrocytes in the cartilage which help produce GAGs and proteoglycans.In humans, about 90 percent of glucosamine, administered as an oral dose of glucosamine sulfate, is absorbed from the digestive tract. Predominantly metabolized by liver & excreted through urine.Diacerein: This is used for the treatment of Osteoarthritis. It has also analgesic, antipyretic and anti-inflammatory activity. It release in vitro and directly inhibits InterLeukin-1(IL-1) synthesis, which is the main cytokine involved in cartilage destruction. Due to specific mode of action, it have been shown to have disease-modifying effect in experimental models of osteoarthritis and in human subjects with finger joint and knee osteoarthritis.Oral bioavailability of Diacerein 56%. Concurrent intake of food delays the time to peak concentration but associated with a 25% increase in absorption. Therefore, diacerein is best given with food. Mainly binds with protein albumin. Diacerein is metabolized extensively (100%) in liver following oral dosing. Urinary excretion of diacerein in the form of its metabolites has ranged between 35% and 60%.

Trade Name Rejoin-D Tablet 750 mg+50 mg
Generic Glucosamine Sulfate + Diacerein
Weight 750 mg+50 mg
Type Tablet
Therapeutic Class Stimulation of Cartilage formation
Manufacturer Aristopharma Ltd.
Available Country Bangladesh
Last Updated: October 19, 2023 at 6:27 am
Rejoin-D Tablet 750 mg+50 mg
Rejoin-D Tablet 750 mg+50 mg

Uses

This tablet is used for-

  • Osteoarthritis
  • Rheumatoid arthritis
  • Bone and Joint injuries

Rejoin-D Tablet 750 mg+50 mg is also used to associated treatment for these conditions: Osteoarthritis in the Hip Joint, Osteoarthritis of the Knee

How Rejoin-D Tablet 750 mg+50 mg works

Diacerein's active metabolite rhein Rhein reduces cartilage destruction by decreasing expression of matrix metalloproteinase (MMP)-1 and -3 as well as upregulating tissue inhibitor of matrix metalloproteinases which serve to reduce the activity of several MMPs . The anti-inflammatory action of rhein reduces the level of interleukin-1beta activity which plays a large role in reduction of extracellular matrix production, MMP activity, and continued inflammation . Rhein reduces abnormal osteoblast synthetic activity through an unknown mechanism .

Dosage

Rejoin-D Tablet 750 mg+50 mg dosage

Use in adults: One tablet twice daily with food.

Use in children and adolescents
: The safety and effectiveness of children and adolescents under the age of 18 years have not been established.

Side Effects

No serious adverse effect has been reported. Nausea, vomiting, diarrhea, epigastria pain, headache, skin rashes & intense yellow coloring of urine may be occurred.

Toxicity

Rhein Rhein has an oral LD50 of >5000mg/kg in mice. This is equivalent to a diacerein dose of >6476mg/kg.

Precaution

Caution should be practised when administering this tablet in case of patients who are allergic to Glucosamine or Diacerein.

Interaction

Decrease absorption of Diacerein with aluminium and/ or magnesium hydroxide antacids. Increase risk of diarrhea with laxatives or antibiotics.

Volume of Distribution

15-60L .

Elimination Route

Bioavailability of 50-60% . Entirely converted to the active metabolite rhein Rhein before reaching systemic circulation.

Half Life

4-10h .

Clearance

Total CL is 1.5L/h and renal CL is 0.1L/h .

Elimination Route

37% excreted in urine and 53% in feces as estimated in rats .

Pregnancy & Breastfeeding use

This tablet is contraindicated during pregnancy and breastfeeding.

Contraindication

Contraindicated for those who shows hypersensitivity to Glucosamine or Diacerein.

Acute Overdose

There is no data available regarding overdose of this combination.

Storage Condition

Store in cool & dry place below 30ÂșC, protect from light & moisture. Keep out of reach of children.

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*** Taking medicines without doctor's advice can cause long-term problems.
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