Renocis

Renocis Uses, Dosage, Side Effects, Food Interaction and all others data.

A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.

Renocis is an orally active, heavy metal chelating agent. It forms water soluble chelates and, consequently, increases the urinary excretion of lead. Renocis is not to be used for prophylaxis of lead poisoning in a lead-containing environment. In addition, the use of succimer should always be accompanied by identification and removal of the source of the lead exposure.

Trade Name Renocis
Availability Prescription only
Generic Succimer
Succimer Other Names DIM-SA, DMS-A, DMSA, meso-dimercaptosuccinic acid, Succimer, succimero
Related Drugs glucagon, mannitol, Tubersol, arginine, inulin, Chemet, Calcium Disodium Versenate
Type
Formula C4H6O4S2
Weight Average: 182.21
Monoisotopic: 181.970751021
Groups Approved
Therapeutic Class
Manufacturer
Available Country France
Last Updated: September 19, 2023 at 7:00 am
Renocis
Renocis

Uses

Renocis is a mercaptodicarboxylic acid heavy metal chelator used in the treatment of heavy metal poisoning.

For the treatment of lead poisoning in pediatric patients with blood lead levels above 45 µg/dL. May also be used to treat mercury or arsenic poisoning.

Renocis is also used to associated treatment for these conditions: Arsenic Poisoning, Mercury Poisoning, Poisoning, Lead, Blood lead levels above 45 mcg/dL Lead poisoning

How Renocis works

Renocis is a heavy metal chelator. It binds with high specificity to ions of lead in the blood to form a water-soluble complex that is subsequently excreted by the kidneys. Renocis can also chelate mercury, cadmium, and arsenic in this manner.

Toxicity

Oral LD50 in mice is over 5011 mg/kg. Doses of 2300 mg/kg in the rat and 2400 mg/kg in the mouse produced ataxia, convulsions, labored respiration and frequently death. No case of overdosage has been reported in humans. Limited data indicate that succimer is dialyzable.

Food Interaction

  • Take with or without food. Capsules may be opened, and contents sprinkled on soft food for individuals with difficulty swallowing.

Elimination Route

Rapid but variable.

Half Life

48 hours

Elimination Route

Unabsorbed drug is excreted primarily in feces and absorbed drug is excreted primarily in the urine as metabolites.

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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