Renocis
Renocis Uses, Dosage, Side Effects, Food Interaction and all others data.
A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.
Renocis is an orally active, heavy metal chelating agent. It forms water soluble chelates and, consequently, increases the urinary excretion of lead. Renocis is not to be used for prophylaxis of lead poisoning in a lead-containing environment. In addition, the use of succimer should always be accompanied by identification and removal of the source of the lead exposure.
| Trade Name | Renocis |
| Availability | Prescription only |
| Generic | Succimer |
| Succimer Other Names | DIM-SA, DMS-A, DMSA, meso-dimercaptosuccinic acid, Succimer, succimero |
| Related Drugs | glucagon, mannitol, Tubersol, arginine, inulin, Chemet, Calcium Disodium Versenate |
| Type | |
| Formula | C4H6O4S2 |
| Weight | Average: 182.21 Monoisotopic: 181.970751021 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | France |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Renocis is a mercaptodicarboxylic acid heavy metal chelator used in the treatment of heavy metal poisoning.
For the treatment of lead poisoning in pediatric patients with blood lead levels above 45 µg/dL. May also be used to treat mercury or arsenic poisoning.
Renocis is also used to associated treatment for these conditions: Arsenic Poisoning, Mercury Poisoning, Poisoning, Lead, Blood lead levels above 45 mcg/dL Lead poisoning
How Renocis works
Renocis is a heavy metal chelator. It binds with high specificity to ions of lead in the blood to form a water-soluble complex that is subsequently excreted by the kidneys. Renocis can also chelate mercury, cadmium, and arsenic in this manner.
Toxicity
Oral LD50 in mice is over 5011 mg/kg. Doses of 2300 mg/kg in the rat and 2400 mg/kg in the mouse produced ataxia, convulsions, labored respiration and frequently death. No case of overdosage has been reported in humans. Limited data indicate that succimer is dialyzable.
Food Interaction
- Take with or without food. Capsules may be opened, and contents sprinkled on soft food for individuals with difficulty swallowing.
Renocis Disease Interaction
Moderate: dehydration, liver disease, neutropenia, renal dysfunction
Elimination Route
Rapid but variable.
Half Life
48 hours
Elimination Route
Unabsorbed drug is excreted primarily in feces and absorbed drug is excreted primarily in the urine as metabolites.
Innovators Monograph
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