Retapamulin
Retapamulin Uses, Dosage, Side Effects, Food Interaction and all others data.
Retapamulin is a semisynthetic derivative of the compound pleuromutilin. In vitro activity of Retapamulin against isolates of Staphylococcus aureus as well as Streptococcus pyogenes has been demonstrated. Retapamulin selectively inhibits bacterial protein synthesis by interacting at a site on the 50S subunit of the bacterial ribosome through an interaction that is different from that of other antibiotics.This binding site involves ribosomal protein L3 and is in the region of the ribosomal P-site and peptidyl transferase center. By virtue of binding to this site, pleuromutilins inhibit peptidyl transfer, block P-site interactions and prevent the normal formation of active 50S ribosomal subunits. Retapamulin demonstrates no in vitro target-specific cross-resistance with other classes of antibiotics.
Retapamulin is a semisynthetic pleuromutilin antibiotic. This drug is usually bacteriostatic in action, but may become bactericidal at highed concentrations (when MBC is 1000 times higher than MIC). Retapamulin acts by selectively inhibiting the initiation of protein synthesis in bacteria at the level of bacterial 50S ribosome.
| Trade Name | Retapamulin |
| Generic | Retapamulin |
| Retapamulin Other Names | Retapamulin, Retapamulina |
| Weight | 1% |
| Type | Topical Application, Topical Ointment |
| Formula | C30H47NO4S |
| Weight | Average: 517.763 Monoisotopic: 517.322579687 |
| Protein binding | Retapamulin is approximately 94% bound to human plasma proteins, and the protein binding is independent of concentration. |
| Groups | Approved |
| Therapeutic Class | Topical Antibiotic preparations |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Retapamulin ointment is used for the topical treatment of impetigo due to Staphylococcus aureus (methicillin-susceptible isolates only) or Streptococcus pyogenes in patients aged 9 months or older. It is also used to treat infected small lacerations, abrasions or sutured wounds.
Retapamulin is also used to associated treatment for these conditions: Staphylococcal impetigo, Streptococcal impetigo
How Retapamulin works
Retapamulin is a bacterial protein synthesis inhibitor belonging to a class of compounds called pleuromutilins. These compounds inhibit the initiation of protein synthesis by binding to a specific site on the 50S subunit of bacterial ribosome (domain V of 23S rRNA). This binding site involves ribosomal protein L3 and is in the region of the ribosomal P site and peptidyl transferase center. By virtue of binding to this site, pleuromutilins inhibit peptidyl transfer, block P-site interactions, and prevent the normal formation of active 50S ribosomal subunits.
Dosage
Retapamulin dosage
Apply a thin layer of Retapamulin to the affected area (up to 100 cm2 in total area in adults or 2% total body surface area in pediatric patients aged 9 months or older) twice daily for 5 days.
The treated area may be covered with a sterile bandage or gauze dressing if desired.
Side Effects
Side effects: Headache, pyrexia, pruritus, eczema, diarrhoea. Application site irritation, pain, erythema, contact dermatitis.
Adverse effects: Application site irritation (<2% of patients may experience).
Precaution
In the event of sensitization or severe local irritation, usage should be discontinued. Not intended for ingestion or for oral, intranasal, ophthalmic, or intravaginal use.
Interaction
The effect of concurrent application of Retapamulin and other topical products to the same area of skin has not been studied.
Food Interaction
No interactions found.Pregnancy & Breastfeeding use
Pregnancy Category B. It is not known whether Retapamulin is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when this product is administered to a nursing woman.
Contraindication
Hypersensitivity.
Storage Condition
Store in a cool (below 25° C)and dry place protected from light. Keep out of the reach of children.
Innovators Monograph
You find simplified version here Retapamulin
Retapamulin contains Retapamulin see full prescribing information from innovator Retapamulin Monograph, Retapamulin MSDS, Retapamulin FDA label
FAQ
What is Retapamulin used for?
Retapamulin is used to treat impetigo (a skin infection caused by bacteria) in children and adults.Retapamulin is in a class of medications called antibacterials.
How safe is Retapamulin?
Topical Retapamulin is effective and safe in the treatment of primary impetigo.
How does Retapamulin work?
Retapamulin works by killing and stopping the growth of bacteria on the skin.
What are the common side effects of Retapamulin?
Common side effects of Retapamulin are include:
- irritation at the in the place where you applied the ointment
- blisters
- burning
- redness
- swelling
- oozing from the place where you applied the ointment
- itching
- diarrhea
- headache
Is Retapamulin safe during breastfeeding?
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Is Retapamulin safe during pregnancy?
exposure to the breastfeeding infant is likely to be negligible since minimal systemic exposure is observed in adults.
How long should I stay on Retapamulin?
Retapamulin is usually recommended that you continue on the treatment for at least 12 months. This is 12 months after you feel quite well again, not 12 months after you first started the medicine.
What kind of antibiotic is Retapamulin?
Retapamulin is in a new class of antibiotics called pleuromutilins.
Who should not take Retapamulin?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What happens if I miss a dose of Retapamulin?
Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.
What happens if I overdose?
An overdose of Retapamulin topical is not expected to be dangerous. Seek emergency medical attention if anyone has accidentally swallowed Retapamulin.
What should I avoid while using Retapamulin topical?
Impetigo is highly contagious and spreads easily from person to person. Avoid sharing personal items such as towels, washcloths, or razors with other people if you are infected with impetigo. Use a clean towel and washcloth each time you bathe to keep from reinfecting your own skin.
Avoid getting this medication in your eyes, nose, or mouth, or inside your vagina. If this does happen, rinse with water.
How should Retapamulin used?
Retapamulin comes as an ointment to be applied in a thin layer to the skin. Retapamulin is usually used two times a day for 5 days. Apply Retapamulin at around the same times every day. .
