Rgnil
Rgnil Uses, Dosage, Side Effects, Food Interaction and all others data.
Invert sugar is obtained from sugar cane when this is treated with dilute acid or with the invertase enzyme. It is formed by an equal amount of glucose and fructose. It differentiates from sugar cane in the rotation of the polarized light, which in the case of invert sugar it is to the left (levorotatory). Invert sugar is FDA approved since 1988 as a safe substance (GRAS).
Intravenous administration of invert sugar has been proven to be favorable. These reports indicate a temporary rise, within physiological levels, of lactate, pyruvate, and insulin in the blood plasma whereas the level of free fatty acids was declined.
Phosphoric Acid is a colorless, odorless phosphorus-containing inorganic acid. Phosphoric acid is a sequestering agent which binds many divalent cations, including Fe++, Cu++, Ca++, and Mg++.
Transport of phosphate from the gut lumen is an active, energy-dependent process that is modified by several factors. ... Vitamin D stimulates phosphate absorption, an effect reported to precede its action on calcium ion transport.
| Trade Name | Rgnil |
| Generic | Invert Sugar + Phosphoric Acid |
| Weight | 3.74g |
| Type | Syrup |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Invert sugar presents a large variety of uses. It can be used therapeutically for parenteral hyperalimentation or to be used as an excipient with a known effect. Invert sugar is also approved for its use in food products as a humectant, crystallization modifier, and liquid and nutritive sweetener.
Phosphoric acid is an ingredient used for electrolyte replenishment and total parenteral nutrition (TPN) therapy, and for the relief of upset stomach associated with nausea.
Phosphoric acid is used in dentistry and orthodontics as an etching solution, to clean and roughen the surfaces of teeth where dental appliances or fillings will be placed.
Rgnil is also used to associated treatment for these conditions: Total parenteral nutrition therapy
How Rgnil works
Phosphate supplementation of the diet of rodents has been shown to lead to reduction in the incidence of dental caries and different phosphates have different powers in reducing the cariogenic potential of the carbohydrates in a diet. Phosphate supplements seem to exert their cariostatic effect on the tooth surface either directly during eating or by excretion in the saliva.
Toxicity
Invert sugar is a generally accepted safe substance and it does not present toxic effects. Do not administer invert sugar in patients with the rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltase insufficiency. It is also recommended to take precautions in patients that present diabetes mellitus.
Man: LDLo, route unreported at 220mg/kg Rabbit: LD 50, Route: Skin, Reported dose: 2740 mg /kg, Effects: Behavioral : somnolence ( general depressed activity), Excitement Rat: LC50, Route: inhalation, Reported dose: >850 mg/m3/1h Rat: LD50, Route: oral, Reported dose: 1530 mg/kg, Effects: Kidney, ureter and bladder hematuria, Behavioral: somnolence (general depressed activity)
Volume of Distribution
Absorbed phosphoric acid is distributed widely in the body as phosphate. Increased serum phosphate concentrations have been reported rarely after phosphoric acid ingestion
Elimination Route
It has been reported that administration of 10-15% of intravenous invert sugar solution is rapidly absorbed in the intestine and distributed in blood without exceeding the renal threshold. The absorption of invert sugar happens mainly as monosaccharides. Glucose is absorbed into the portal vein by the transporter GLUT2 while fructose is absorbed by the transporter GLUT5.
Ortho phosphate is absorbed from, and to a limited extent secreted into, the gastrointestinal tract.
Half Life
The glucose half-life following intravenous administration of invert sugar is of approximately 30 min. In the same report, the half-life of fructose after the intravenous administration is reported to be 16 min.
In infants with normal renal function the serum half-life of phosphate following single oral or rectal overdose is 5-11 hours
Clearance
Absorbed phosphate is filtered at the glomerulus and partially reabsorbed, with phosphate clearance 80 per cent of creatinine clearance.
Elimination Route
Reports have indicated that after intravenous administration of invert sugar present a reduced content or carbohydrates in urine when compared to the intravenous administration of glucose. This response indicates a reduced diuresis of invert sugar. It has also been reported a reduced diuresis in the presence of invert diuresis.
In adults, about two thirds of the ingested phosphate is absorbed, and that which is absorbed is almost entirely excreted into the urine.
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