rhMBL
rhMBL Uses, Dosage, Side Effects, Food Interaction and all others data.
rhMBL is a protein therapeutic being developed by Enzon for the prevention and treatment of severe infections in individuals with low levels of Mannose-Binding Lectin (MBL). Over 10 percent of the general population is estimated to be MBL-deficient. Natural MBL is a 400-700kDa oligomer made of 3 identical 32kDa peptide chains.
MBL forms different oligomers but must form at least a tetramer to be active.
| Trade Name | rhMBL |
| Generic | rhMBL |
| rhMBL Other Names | Recombinant human mannan-binding protein, Recombinant human mannose-binding lectin, rhMBP |
| Type | |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in immunodeficiency and infectious and parasitic disease (unspecified).
How rhMBL works
MBL deficiency may explain why some but not all individuals who are immunosuppressed develop infectious complications even when they receive prophylactic anti-infectious treatment. Studies have shown a correlation between low MBL levels and susceptibility to serious infections in patients immunosuppressed from chemotherapy, including patients with multiple myeloma undergoing high-dose chemotherapy and hematopoietic stem cell transplantation. rhMBL acts as natural MBL in the body, reducing susceptibility to serious infections.
Innovators Monograph
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