rianest

rianest Uses, Dosage, Side Effects, Food Interaction and all others data.

rianest has fungistatic or fungicidal activity against variety of pathogenic and nonpathogenic yeast and fungi, including Candida albicans. rianest exerts its antifungal activity by binding to sterols in the fungal cell membrane. As a result of binding, the membrane is no longer able to function as a selective barrier, and potassium and other cellular constituents are lost. It is poorly absorbed from the gastrointestinal tract.

rianest is an antifungal that is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi. It exerts its antifungal effects via disruption of the fungal cell membrane. Resistance to nystatin is minimal in Candida albicans, but tends to develop in other species of Candida. rianest carries no significant activity against bacteria, protozoa, or viruses. It carries significant systemic toxicity and is currently unavailable in a formula appropriate for systemic use - its efficacy is currently restricted, therefore, to topical, oral, and gastrointestinal infections.

Trade Name rianest
Availability Prescription only
Generic Nystatin
Nystatin Other Names Nistatina, Nystatin, Nystatine, Nystatinum
Related Drugs fluconazole, clotrimazole, Diflucan, itraconazole, miconazole, Mycostatin, Nilstat
Weight 100000iu/ml, 100000iu
Type Suspension, Cream, Ointment
Formula C47H75NO17
Weight Average: 926.107
Monoisotopic: 925.503499959
Protein binding

Nystatin is not absorbed into the systemic circulation and is therefore not subject to plasma protein binding.

Groups Approved, Vet approved
Therapeutic Class Drugs for subcutaneous and systemic mycoses, Drugs used in Vaginal and Vulval condition
Manufacturer Riyadh Pharma
Available Country Saudi Arabia
Last Updated: September 19, 2023 at 7:00 am
rianest
rianest

Uses

rianest Cream is used for the treatment of cutaneous or mucocutaneous mycotic infections caused by Candida albicans and other susceptible Candida species. This cream is not used for systemic, oral, intravaginal or ophthalmic use.

rianest tablet is an antifungal antibiotic active against a wide range of yeasts and yeast like fungi including Candida albicans. It is used for the prevention and treatment of Candida infections of oral cavity, esophagus and intestinal tract. It provides effective prophylaxis against oral candidiasis in those born of mothers with vaginal candidiasis. It is used for the prophylaxis of Candida overgrowth during courses of broadspectrum antibiotics

rianest is also used to associated treatment for these conditions: Anal candidiasis, Candidiasis, Invasive, Intestinal Candidiasis, Mixed Vaginal Infections caused by Trichomonas Vaginalis, candida albicans, Oral Candidiasis, Pruritus Ani, Pruritus Vulvae, Skin candida, Trichomonas Vaginitis, Vaginal Candidiasis, Vulvovaginal Candidiasis, Corticosteroid-responsive dermatoses, Cutaneous candidiasis

How rianest works

rianest is a channel-forming ionophore, meaning it exerts its therapeutic effect via formation of a membrane-spanning pore in the fungal plasma membrane. The formation of this pore results in a change in membrane permeability that allows for leakage of intracellular contents and the subsequent disruption of electrochemical gradients necessary for proper cell function. Selectivity for fungal cells over mammalian cells is due to nystatin’s greater binding affinity for ergosterol, a key sterol found in fungal cell walls, as opposed to its mammalian counterpart, cholesterol.

Dosage

rianest dosage

Children:

  • In intestinal and oral candidiasis (thrush): 1,00,000 units (1 ml) should be dropped into the mouth four times daily.The longer the suspension is kept in contact with the affected area in the mouth, before swallowing, the greater will be its effect.
  • For prophylaxis in the newborn:The suggested dose is 1,00,000 units (1 ml) once daily or as prescribed by the physician.

Adult:

  • For the treatment of intestinal or esophageal candidiasis: 5,00,000 units (5 ml) by mouth 3 or 4 times daily. The dose may be doubled, if required.
  • For prophylaxis of intestinal candidiasis in adults: 10,00,000 units (10 ml) daily.
  • For prophylaxis to suppress the over growth of Candida albicans in patients receiving broad spectrum antibiotic therapy: 10,00,000 units (10 ml) daily.
  • For the treatment of dental sores and oral infection: 1,00,000 units (1 ml) suspension should be dropped into the mouth four times daily.

Elderly: Older people with intestinal candidiasis who are unable to swallow tablets should be given 5,00,000 units (5 ml) suspension four times daily.

Adults and Pediatric Patients (Neonates and Older): Apply liberally to affected areas twice daily or as indicated until healing is complete.

Pediatric Use: Safety and effectiveness have been established in the pediatric population from birth to 16 years.

Geriatric Use: Clinical studies with nystatin cream did not include sufficient numbers of subjects aged 65 years and older to determine whether they respond differently than younger subjects. Other reported clinical experience has not identified differences in responses between elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.

Side Effects

rianest cream: The frequency of adverse events reported in patients using nystatin cream is less than 0.1%. The more common events that were reported include allergic reactions, burning, itching, rash, eczema, and pain on application.

rianest tablet: Nausea, vomiting and diarrhoea have occasionally been reported with high doses of rianest. No systemic effects or allergic reactions have been associated with its oral dose.

Toxicity

The oral LD50 in rats is 10 g/kg. There have been no reports of serious toxic effects following overdosage of nystatin - doses in excess of five million units daily have resulted in nausea and gastrointestinal upset with no other associated effects.

Precaution

rianest cream should not be used for the treatment of systemic, oral, intravaginal or ophthalmic infections. If irritation or sensitization develops, treatment should be discontinued and appropriate measures taken as indicated. It is recommended that KOH smears, cultures, or other diagnostic methods be used to confirm the diagnosis of cutaneous or mucocutaneous candidiasis and to rule out infection caused by other pathogens.

Absorption from the gastrointestinal tract is negligible, therefore no special precaution is required to apply in pregnancy and lactation

Food Interaction

No interactions found.

Volume of Distribution

rianest is not absorbed into the systemic circulation and thus does not undergo distribution.

Elimination Route

Systemic absorption of nystatin is minimal following oral administration, and no detectable plasma concentrations are attained following topical or vaginal administration.

Elimination Route

The majority of orally administered nystatin is eliminated unchanged in the feces.

Pregnancy & Breastfeeding use

Pregnancy Category C. Animal reproduction studies have not been conducted with any nystatin cream. It also is not known whether this cream can cause fetal harm when used by a pregnant woman or can affect reproductive capacity. rianest cream should be prescribed for a pregnant woman only if the potential benefit to the mother outweighs the potential risk to the fetus.

Nursing Mothers: It is not known whether nystatin is excreted in human milk. Caution should be exercised when nystatin is prescribed for a nursing woman.

Mouth/Throat/PO/Topical: Pregnancy catagory C

Vaginal: Pregnancy catagory A

Contraindication

rianest cream is contraindicated in patients with a history of hypersensitivity to any of its components.

There is no known contraindication to the use of rianest oral.

Storage Condition

Store at 20° to 25°C. Avoid freezing.

Innovators Monograph

You find simplified version here rianest

rianest contains Nystatin see full prescribing information from innovator rianest Monograph, rianest MSDS, rianest FDA label

FAQ

What is rianest used to treat?

rianest is an antifungal medicine. It's used to treat or prevent infections caused by a fungus.

How safe is rianest?

rianest is generally very safe. Taking too much is unlikely to harm you or your child. If you're worried, speak to your pharmacist or doctor.

How does rianest work?

rianest work by kills the fungus and treats the infection. If you're taking rianest to prevent an infection, the medicine kills any fungus as it starts to appear.

What are the common side effects of rianest?

Common side effects of rianest may include: mouth irritation; upset stomach, nausea, vomiting, diarrhea; skin rash.

Is rianest safe during pregnancy?

Topical rianest is a safe alternative to azole anti-fungals that has been extensively studied in the first trimester of pregnancy. As rianest has negligible systemic absorption, no associated risk of major malformations has been observed in numerous trials.

Is rianest safe during breastfeeding?

It's usually safe to take rianest liquid while you're breastfeeding.

Can I drink alcohol with rianest?

Avoid drinking alcohol while taking this drug and for at least 1 day after the last dose. Drinking alcohol or taking products that have alcohol may cause flushing, throwing up, or fast heartbeat. Have blood work checked as you have been told by the doctor.

How many days does it take for rianest to work?

rianest usually starts to work after 2 days. It's important to continue to take or use rianest for 2 days after your condition is better. This will help to stop it coming back again.

When is the best time to take rianest?

You usually take rianest liquid 4 times a day after meals and before bedtime. It's important not to eat or drink for 30 minutes after taking the liquid.

Do I take rianest with food or without food?

You can take rianest with or without food.

What does rianest do for thrush?

rianest is also quite common for young babies to have oral thrush.rianest suspension (drops) are an option for the treatment of oral thrush.

Can I take rianest for a long time?

People usually only take rianest for around a week to clear the infection. If you're using a rianest cream or ointment mixed with other ingredients, only use for longer than 7 days if your doctor tells you to.

How long can I stay on rianest?

Most doctors recommend that you continue to use the drops for two days after your symptoms have gone a typical course of treatment will last around seven days.

Who should not take rianest?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What are the contraindications for rianest?

rianest tablets are contraindicated in patients with a history of hypersensitivity to any of their components.

Is rianest safe for adults?

Most adults and children, including babies, can take nystatin liquid or use nystatin cream and ointments.

Can rianest cause liver damage?

rianest is considered very safe and is unlikely to cause hepatic injury.

Can rianest cause stomach pain?

rianest can causes stomach pain also with other side effects.

What happen If I missed rianest?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I take too much rianest?

rianest is generally very safe. Taking too much is unlikely to harm you or your child. If you're worried, speak to your pharmacist or doctor.

Can rianest cure yeast infection?

rianest topical (for the skin) is used to treat skin infections caused by yeast.rianest topical is not for use to treat a vaginal yeast infection.

*** Taking medicines without doctor's advice can cause long-term problems.
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