Rillus

Rillus Uses, Dosage, Side Effects, Food Interaction and all others data.

Lactobacillus plantarum is a member of Lactobacillus, or lactic acid bacteria, that it is widely used in the food industry as a microbial starter and probiotic microorganism. It is considered to be one of versatile species that carry out fermentative and metabolic processes, while exhibiting an antagonistic activity against pathogenic and spoilage microorganisms. L. plantarum produces different antimicrobial agents such as organic acids, hydrogen peroxide, diacetyl, bacteriocins, and antimicrobial peptides .

Xylitol is a naturally occurring five-carbon sugar alcohol found in most plant material, including many fruits and vegetables. Xylitol-rich plant materials include birch and beechwood . It is widely used as a sugar substitute and in "sugar-free" food products. The effects of xylitol on dental caries have been widely studied, and xylitol is added to some chewing gums and other oral care products to prevent tooth decay and dry mouth. Xylitol is a non-fermentable sugar alcohol by most plaque bacteria, indicating that it cannot be fermented into cariogenic acid end-products . It works by inhibiting the growth of the microorganisms present in plaque and saliva after it accummulates intracellularly into the microorganism . The recommended dose of xylitol for dental caries prevention is 6–10 g/day, and most adults can tolerate 40 g/day without adverse events .

There has been evidence of xylitol in dental hygiene in reducing dental caries disease and also reversing the process of early caries . Xylitol increases salivary flow and pH, reduces the levels of Streptococcus mutans in plaque and saliva and reduces the adhesion on the microorganism to the teeth surface . Streptococcus mutans is the main target plaque microorganism , but xylitol may potentially have inhibitory actions against several other bacterial species .It prevents a shift of the bacterial community towards a more cariogenic microflora in oral environment . Oral ingestion of xylitol causes a smaller rise in plasma glucose and insulin concentrations than does the ingestion of glucose in healthy men and diabetics .

Rillus
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Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
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Trade Name	Rillus
Generic	Lactobacillus plantarum + Streptococcus thermophilus + Bifidobacterium bifidum + Fructooligosaccharide + Bahan lainnya: isomalt + xylitol + perisa susu + perisa vanila.
Weight	8.55mg, 8.55mg, 2.55mg, 480mg
Type	Tablet
Therapeutic Class
Manufacturer	Kalbe Farma
Available Country	Indonesia
Last Updated:	September 19, 2023 at 7:00 am

Uses

Streptococcus thermophilus is a bacterial culture indicated in some treatments of diarrhea.

Xylitol is an ingredient added to dental products to remove bacteria.

Indicated for use as a sugar substitute, and oral hygiene active ingredient.

Rillus is also used to associated treatment for these conditions: Gut Health, Infectious diarrhea, Trichomonas Vaginitis, Vaginal Infections, Vaginal Inflammation, VulvovaginitisDiarrhoea

How Rillus works

Xylitol is initially taken up by the microorganism and accumulates intracellularly. Accumulated xylitol is transported into an energy-consuming cycle, or the inducible fructose transport system. It is converted to non-metabolizable, toxic xylitol-5-phosphate via phosphoenolpyruvate: a constitutive fructose phosphotransferase system by S. mutans . This metabolic process of xylitol, without the gain of any energy molecules, results in the development of intracellular vacuoles and cell membrane degradation. S. mutans dephosphorylates xylitol-5-phosphate and expels it from the cell, in which requires energy consumption. This ultimately leading to starving of microorganism and growth inhibition . Long-term exposure to xylitol can cause microorganisms to develop resistance to xylitol. This clinically beneficial selection process creates xylitol-resistant mutans strains that are less virulent and less cariogenic than their parent strains . Xylitol also increases the concentrations of ammonia and amino acids in plaque, thereby neutralizing plaque acids . A study suggests that xylitol may also promote remineralization of deeper layers of demineralized enamel by facilitating Ca2+ and phosphate movement and accessibility .