Rimantadine hydrochloride

Rimantadine hydrochloride Uses, Dosage, Side Effects, Food Interaction and all others data.

An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.

Rimantadine hydrochloride, a cyclic amine, is a synthetic antiviral drug and a derivate of adamantane, like a similar drug amantadine. Rimantadine hydrochloride is inhibitory to the in vitro replication of influenza A virus isolates from each of the three antigenic subtypes (H1N1, H2H2 and H3N2) that have been isolated from man. Rimantadine hydrochloride has little or no activity against influenza B virus. Rimantadine hydrochloride does not appear to interfere with the immunogenicity of inactivated influenza A vaccine.

Trade Name Rimantadine hydrochloride
Availability Prescription only
Generic Rimantadine
Rimantadine Other Names alpha-Methyladamantanemethylamine, Rimantadina, Rimantadine, Rimantadinum
Related Drugs amantadine, Tamiflu, oseltamivir, Fluzone, Xofluza, Afluria, Fluad, Flumadine
Type
Formula C12H21N
Weight Average: 179.3018
Monoisotopic: 179.167399677
Protein binding

Approximately 40% over typical plasma concentrations.

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country Germany, Russia
Last Updated: September 19, 2023 at 7:00 am
Rimantadine hydrochloride
Rimantadine hydrochloride

Uses

Rimantadine hydrochloride is an RNA synthesis inhibitor used to prevent influenza A infection.

For the prophylaxis and treatment of illness caused by various strains of influenza A virus in adults.

Rimantadine hydrochloride is also used to associated treatment for these conditions: Influenza A Virus Infection

How Rimantadine hydrochloride works

The mechanism of action of rimantadine is not fully understood. Rimantadine hydrochloride appears to exert its inhibitory effect early in the viral replicative cycle, possibly inhibiting the uncoating of the virus. The protein coded by the M2 gene of influenza A may play an important role in rimantadine susceptibility.

Toxicity

Oral LD50 in rats is 640 mg/kg. Overdoses of a related rug, amantadine, have been reported with adverse reactions consisting of agitation, hallucinations, cardiac arrhythmia and death.

Food Interaction

No interactions found.

Rimantadine hydrochloride Disease Interaction

Moderate: liver disease, renal dysfunction, seizure disorders

Elimination Route

Well absorbed, with the tablet and syrup formulations being equally absorbed after oral administration.

Half Life

25 to 30 hours in young adults (22 to 44 years old). Approximately 32 hours in elderly (71 to 79 years old) and in patients with chronic liver disease. Approximately 13 to 38 hours in children (4 to 8 years old).

Elimination Route

Following oral administration, rimantadine is extensively metabolized in the liver with less than 25% of the dose excreted in the urine as unchanged drug.

Innovators Monograph

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