Rinosedin für Kleinkinder 0.05%

Rinosedin für Kleinkinder 0.05% Uses, Dosage, Side Effects, Food Interaction and all others data.

Rinosedin für Kleinkinder 0.05% is a sympathomimetic agent with marked alphaadrenergic activity, and is intended for use in the nose. It constricts the nasal blood vessels, thereby decongesting the mucosa of the nose and neighboring regions of the pharynx. This enables patients suffering from colds to breathe more easily through the nose. The effect of Rinosedin für Kleinkinder 0.05% begins within a few minutes and persists for several hours. Rinosedin für Kleinkinder 0.05% is generally well tolerated and does not impair the function of ciliated epithelium. Systemic absorption may occur following nasal application of Rinosedin für Kleinkinder 0.05%.

Rinosedin für Kleinkinder 0.05% is a sympathomimetic agent that causes vasoconstriction of the nasal mucosa. In one study comprising subjects with nasal congestion associated with the common cold, the median time of onset of subjective relief of nasal congestion was about 1.7 minutes and the time of subjective peak relief of nasal congestion was 30 minutes. Previous studies reported rebound swelling, rebound nasal congestion, rhinitis medicamentosa, and shorter duration of decongestant effect from the long-term use of xylometazoline in healthy volunteers, suggesting that the drug is most effective if used temporarily.

An early in vitro study demonstrated xylometazoline to exert anti-oxidant actions, where it inhibited microsomal lipid peroxidation and mediated hydroxyl radical scavenging activity. This suggests that xylometazoline has a beneficial effect against oxidants, which play a role in tissue damage in inflammation.

Trade Name Rinosedin für Kleinkinder 0.05%
Generic Xylometazoline
Xylometazoline Other Names Xylometazoline, Xylometazolinum, Xylomethazoline
Type
Formula C16H24N2
Weight Average: 244.3752
Monoisotopic: 244.193948778
Protein binding

No information is available on xylometazoline pharmacokinetics.

Groups Approved, Investigational
Therapeutic Class Nasal Anti-histamine preparations
Manufacturer
Available Country Switzerland
Last Updated: September 19, 2023 at 7:00 am
Rinosedin für Kleinkinder 0.05%
Rinosedin für Kleinkinder 0.05%

Uses

For the symptomatic relief of nasal congestion, perennial allergic rhinitis (including hay fever), sinusitis.

Rinosedin für Kleinkinder 0.05% is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Nasal Congestion, Seasonal Allergic Rhinitis

How Rinosedin für Kleinkinder 0.05% works

Nasal congestion is caused by various etiologies, such as rhinosinusitis and allergic or non-allergic rhinitis, leading to congestion of the venous sinusoids lining the nasal mucosa. Activation of α-adrenergic receptors leads to vasoconstriction of the blood vessels of the nasal mucosa and resumption of nasal airflow. As the most abundantly expressed in the human nasal mucosa, α1A- and α2B-adrenoceptors may play the most important role in vasoconstriction of the human nasal mucosa. Rinosedin für Kleinkinder 0.05% is a more selective agonist at α2B-adrenoceptors, with affinity at α1A-, α2A-, α2C-, α1B-, and α1D-adrenoceptors. Rinosedin für Kleinkinder 0.05% decreases nasal resistance during inspiration and expiration and increases the volume of nasal airflow. Compared to oxymetazoline, another imidazoline nasal decongestant, xylometazoline had a slightly faster onset of action although they had a similar duration of action. In one study, subjects with nasal congestion reported relief of earache and sore throat in addition to nasal decongestion: it is speculated that oxymetazoline mediates this effect by causing vasoconstriction of the nasal mucosa that contains the venous sinuses and nasal decongestion allows breathing through the nose, providing relief from sore throat caused by mouth breathing that dries and irritates the throat.

Dosage

Rinosedin für Kleinkinder 0.05% dosage

Adults: 2 or 3 drops of Rinosedin für Kleinkinder 0.05% Adult formula (0.1%) two to three times daily. This adult formula should not be used for children under the age of 12 years.Children under 12 years: 1 or 2 drops of the Rinosedin für Kleinkinder 0.05% children's formula (0.05%) in each nostril once or twice daily. Not to be used in infants less than 3 months.

Side Effects

The following side effects have occasionally been encountered: a burning sensation in the nose and throat, local irritation, nausea, headache, and dryness of the nasal mucosa. Systemic cardiovascular effects have occurred, and this should be kept in mind when giving Rinosedin für Kleinkinder 0.05% to people with cardiovascular disease.

Toxicity

The oral LD50 is 230 mg/kg in rats and 75 mg/kg in mice. The subcutaneous LD50 is 90 mg/kg in rats and 53 mg/kg in mice. The intraperitoneal LD50 is 43 mg/kg in rats.

Rinosedin für Kleinkinder 0.05% poisoning is documented in three pediatric patients who were exposed to a drug concentration 40 times above the adequate dosage for children due to a compounding error: these patients experienced bradypnea and sinus bradycardia with supraventricular extrasystoles and were managed with fluid management.

Precaution

Each Rinosedin für Kleinkinder 0.05% pack should be used by one person only to prevent any cross-infection. Patients are advised not to take decongestants for more than seven consecutive days.

Interaction

No drug interactions have been reported.

Food Interaction

No interactions found.

Volume of Distribution

No information is available on xylometazoline pharmacokinetics.

Elimination Route

No information is available on xylometazoline pharmacokinetics.

Half Life

No information is available on xylometazoline pharmacokinetics.

Clearance

No information is available on xylometazoline pharmacokinetics.

Elimination Route

No information is available on xylometazoline pharmacokinetics.

Pregnancy & Breastfeeding use

No foetal toxicity or fertility studies have been carried out in animals. In view of its potential systemic vasoconstrictor effect, it is advisable to take the precaution of not using Rinosedin für Kleinkinder 0.05% during pregnancy

Contraindication

Rinosedin für Kleinkinder 0.05% nasal drops is contraindicated in patients with trans-sphenoidal hypophysectomy or surgery exposing the dura mater. It is also contraindicated in patients who are hypersensitive to Rinosedin für Kleinkinder 0.05%.

Storage Condition

Protect from heat. For reasons of hygiene, do not use the bottle more than 28 days after opening it.

FAQ

What is xylometazoline used for?

bnrand used for temporary relief of congestion in the nose caused by various conditions including the common cold, sinusitis, hay fever, and allergies. It works by narrowing the blood vessels in the nose area, reducing swelling and congestion.

How safe Rinosedin für Kleinkinder 0.05% is?

 Using too much of this Rinosedin für Kleinkinder 0.05% can cause damage to your nasal passages, which may lead to chronic congestion.

What are the common side effects of Rinosedin für Kleinkinder 0.05% ?

Rinosedin für Kleinkinder 0.05% common side effects are include:

  • Nose irritation.
  • Sneezing.
  • Burning.
  • Tingling.
  • Runny nose.
  • Headache.
  • Dry nose.
  • Upset stomach.

Is Rinosedin für Kleinkinder 0.05% safe during pregnancy?

You should only use Rinosedin für Kleinkinder 0.05% during pregnancy if recommended by your doctor.

Is Rinosedin für Kleinkinder 0.05% safe during breastfeeding?

Rinosedin für Kleinkinder 0.05% are effective in relieving nasal congestion but do not produce wakefulness nor reduce milk supply.They are safe and effective but should not be used long term.

Can I drink alcohol with Rinosedin für Kleinkinder 0.05%?

No interactions were found between Alcohol and Rinosedin für Kleinkinder 0.05%. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

How long does Rinosedin für Kleinkinder 0.05% stay in your system?

Long term use(> 10 days) is not recommended due to a rhinitis medicamentosa when stopped. bnrand is in the decongestant and alpha-adrenergic agonist families of medication.

Can I swallow Rinosedin für Kleinkinder 0.05%?

Do not swallow the medication.Rinosedin für Kleinkinder 0.05% nasal spray is only for use in the nose.

Does Rinosedin für Kleinkinder 0.05% get me high?

An Rinosedin für Kleinkinder 0.05% high isn't necessarily a strong high, but it does exist and can have severe consequences. If a person uses nasal sprays excessively, it can cause psychosis.

Does Rinosedin für Kleinkinder 0.05% raise blood pressure?

 Rinosedin für Kleinkinder 0.05% can also cause an increase in blood pressure.

Is Rinosedin für Kleinkinder 0.05% a stimulant?

The most popular topical preparations contain Rinosedin für Kleinkinder 0.05% , which have a long duration of action. Prolonged use can be associated with the risk of rebound congestion, so they can be recommended for occasional limited use for a few days only.

Does Rinosedin für Kleinkinder 0.05% cause addiction?

Rinosedin für Kleinkinder 0.05% have no chemicals these bad for your body, but they can also lead to addiction and recurring symptoms that worsen over time.

Can I take Rinosedin für Kleinkinder 0.05% for a long time?

Children aged 6-12 years should not use Rinosedin für Kleinkinder 0.05% for longer than five days at a time, but adults and children over 12 years of age can use it for up to seven days if needed.

How many days can I use Rinosedin für Kleinkinder 0.05%?

Do not use Rinosedin für Kleinkinder 0.05% nasal spray for longer than 3 days. If your symptoms do not get better after 3 days of treatment, stop using Rinosedin für Kleinkinder 0.05% and call your doctor.

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http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:10082
http://www.hmdb.ca/metabolites/HMDB0015640
http://www.genome.jp/dbget-bin/www_bget?drug:D08684
http://www.genome.jp/dbget-bin/www_bget?cpd:C07913
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5709
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443248
https://www.chemspider.com/Chemical-Structure.5507.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30703
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=39841
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=10082
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL312448
https://zinc.docking.org/substances/ZINC000000057534
http://www.pharmgkb.org/drug/PA165958368
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=517
https://en.wikipedia.org/wiki/Xylometazoline
*** Taking medicines without doctor's advice can cause long-term problems.
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