Ritol
Ritol Uses, Dosage, Side Effects, Food Interaction and all others data.
A selective β2-adrenoceptor agonist with its main action on the uterus, causing relaxation. It reduces the intensity and frequency of contractions. Heart rate is also increased while diastolic pressure is reduced. May cause bronchial relaxation but this is not clinically significant in its usage.
Beta-2 adrenergic receptors are located at sympathetic neuroeffector junctions of many organs, including uterus. Ritol is beta-2 adrenergic agonist. It stimulates beta-2 adrenergic receptor, increases cAMP level and decreases intracellular calcium concentration. The decrease of calcium concentration leads to a relaxation of uterine smooth muscle and, therefore, a decrease in premature uterine contractions.
Trade Name | Ritol |
Availability | Discontinued |
Generic | Ritodrine |
Ritodrine Other Names | Ritodrina, Ritodrine, Ritodrinium |
Related Drugs | nifedipine, progesterone, terbutaline, Prometrium, Crinone |
Type | Tablet |
Formula | C17H21NO3 |
Weight | Average: 287.3535 Monoisotopic: 287.152143543 |
Protein binding | ~56% |
Groups | Approved, Investigational |
Therapeutic Class | Drugs acting on the Uterus |
Manufacturer | Kamron Laboratories Ltd |
Available Country | India |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Ritol is used for the treatment of uncomplicated premature labour
Ritol is also used to associated treatment for these conditions: Foetal distress syndrome, Premature Births, Premature Labour, Uterine Contractions
How Ritol works
Ritol is beta-2 adrenergic agonist. It binds to beta-2 adrenergic receptors on outer membrane of myometrial cell, activates adenyl cyclase to increase the level of cAMP which decreases intracellular calcium and leads to a decrease of uterine contractions.
Dosage
Ritol dosage
By intravenous infusion: Initially 50 mcg/minute, increased gradually according to response by 50 mcg/minute every 10 minutes until contractions stop or maternal heart rate reaches 140 beats/minute; continue for 12–48 hours after contractions cease (usual rate 150–350 mcg/minute); maximum rate 350 mcg/minute.
Intramuscular injection: 10 mg in every 3–8 hours continued for 12–48 hours after contractions have ceased; then by mouth.
Oral maintenance treatment: One tablet (10 mg) may be given approximately 30 minutes before termination of intravenous therapy, repeated every 2 hours for 24 hours, followed by 10–20 mg every 4–6 hours, maximum oral dose 120 mg daily
Side Effects
The common side-effects of ritodrine hydrochloride are nausea, vomiting, flushing, sweating, tremor, hypokalaemia, tachycardia, palpitations, hypotension (left lateral position throughout infusion to minimize risk), uterine bleeding, pulmonary oedema; chest pain or tightness, arrhythmias and salivary gland enlargement. On prolonged administration for several weeks may cause leucopenia and agranulocytosis; liver function abnormalities including increased transaminases and hepatitis.
Toxicity
LD50=64mg/kg (mice, IV); LD50=540 mg/kg (mice, oral); LD50=85 mg/kg (rat, IV)
Precaution
It should be used cautiously in patient with suspected cardiac diseases, hypertension, hyperthyroidism, hypokalaemia, diabetes mellitus, mild to moderate preeclampsia, monitor blood pressure and pulse rate and avoid over-hydration during taking ritodrine hydrochloride.
Interaction
Increased risk of hypokalamia if high doses of corticosteroids, diuretics (acetazalamide, loop diuretics and thiazides) or theophylline given with high doses of ritodrine. A sufficient time interval should elapse prior to administration of another sympathomimetic drug. β–adrenergic blocking drugs inhibit its action; coadministraton of these drugs should, therefore, be avoided. With anesthetics used in surgery, the possibility that hypotensive effects may be potentiated should be considered.
Food Interaction
No interactions found.Ritol Drug Interaction
Moderate: promethazineMinor: betamethasoneUnknown: imiquimod topical, zolpidem, benzocaine topical, cefazolin, hydralazine, phytonadione, donepezil, diphenhydramine, dinoprostone topical, meperidine, erythromycin ophthalmic, methylergonovine, ibuprofen, acetaminophen / oxycodone, metoclopramide, rho , acetaminophen, acetaminophen / codeine
Half Life
1.7-2.6 hours
Pregnancy & Breastfeeding use
Ritol is a drug of pregnancy category B. There are no adequate and well controlled studies of effects in pregnant women before 20 weeks gestation; therefore, this drug should not be used before the 20th week of pregnancy. Studies in pregnant women from the 20th week of gestation onwards have not shown increased risk of fetal abnormalities. Nonetheless, although clinical studies did not indicate a risk of permanent adverse fetal effects from ritodrine, the possibility cannot be excluded; therefore, it should be used only when clearly indicated. In frequently reported neonatal symptoms include hypoglycemia and ileus. In addition, hypocalcemia and hypotension have been reported in neonates whose mothers were treated with other beta mimetic agents. Caution should be exercised unless the potential benefit of treatment to the mother outweighs any possible risk of the infants.
Contraindication
It is contraindicated in patients with known hypersensitivity to the active ingredient or any of the excipients of this component. β2-agonists are contra-indicated in cardiac disease and in patients with significant risk factors for myocardial ischaemia; they should also be avoided in antepartum haemorrhage, intra-uterine infection, intra-uterine fetal death, placenta praevia, abruptio placenta, threatened miscarriage, cord compression, and eclampsia or severe preeclampsia.
Acute Overdose
Symptoms of overdosage are tachycardia (maternal and fetal), palpitation, cardiac arrhythmia, hypotension, nervousness, tremor, nausea and vomiting. If an excess of ritodrine tablets is ingested, gastric lavage or induction of emesis should be carried out followed by administration of activated charcoal. When symptoms of overdose occur as a result of parenteral administration, ritodrine should be discontinued; an appropriate β-blocking agent may be usedas an antidote.
Storage Condition
Keep away from the reach of the children. Store in cool & dry place protected from light
Innovators Monograph
You find simplified version here Ritol
FAQ
What is Ritol used for?
Ritol is used to stop premature labor. This medicine was available only with your doctor's prescription.
How safe is Ritol?
The use of Ritol during pregnancy is generally associated with higher hazard of autism, even after adjusting confounders such as maternal age, neonatal birth weight, preterm birth, preterm labor and steroid use.
How does Ritol work?
Ritol working by decreases intracellular calcium concentration.The Ritol decrease of calcium concentration leads to a relaxation of uterine smooth muscle and, therefore, a decrease in premature uterine contractions.
What are the common side effects of Ritol?
Common side effects of Ritol are include:
- Blurred vision
- chest pain or tightness
- dizziness or lightheadedness
- drowsiness
- dry mouth
- fast or irregular heartbeat—rare with oral form
- flushed and dry skin
- fruit-like breath odor
- increased urination
- loss of appetite
- nausea
- severe pounding or racing heartbeat—rare with oral form
- shortness of breath—rare with oral form
- sleepiness
- stomachache
- tiredness
- troubled breathing (rapid and deep)
- unusual thirst
- vomiting
Is Ritol safe during pregnancy?
There are no controlled data in human pregnancy. Neonatal hypoglycemia, tachycardia, and ileus have been reported. Rarely, ketoacidosis resulting in fetal death has been reported. Ritol is only recommended for use during pregnancy when benefit outweighs risk.
Is Ritol safe during breastfeeding?
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
When should be best taken of Ritol?
first twenty-four hours after the doctor stops your intravenous Ritol, your dose may be as high as 10 milligrams (mg) every two hours. After that, the dose is usually 10 to 20 mg every four to six hours.
How often can I take Ritol?
Ritol is usually 40 mg every eight to twelve hours.
Can I drink alcohol with Ritol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Can Ritol effects my heart?
Ritol should be used with caution if you have heart problems as this medicine may increase the risk of irregular heartbeat and alters your blood pressure. Your doctor may suggest tests to monitor your electrolyte levels and the functioning of your heart.
What happens if I miss a dose?
If you miss a dose of Ritol, take the missed dose as soon as you remember. If it is time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
Can I overdose on Ritol?
Never take more than the prescribed dose. Seek emergency medical treatment in case of a suspected overdose of Ritol.
What is the mechanism of action of Ritol?
The effect of Ritol can be observed within 5 minutes when administered intravenously. It is not known when this medicine starts its action after oral administration.
What is the effect of Ritol on the Liver?
Ritol is not harmful for the liver.
What is the effect of Ritol on the Kidneys?
Ritol is completely safe for kidney.
Does Ritol cause hyperglycemia?
Ritol the main traditional drug in Japan, is a beta-2 stimulant that causes maternal hyperglycemia.