Rolid Tablet 300 mg
Rolid Tablet 300 mg Uses, Dosage, Side Effects, Food Interaction and all others data.
Rolid Tablet 300 mg inhibits protein synthesis by irreversibly binding to the 50s ribosomal subunits thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting in stunted cell growth.
Rolid Tablet 300 mg has the following antibacterial spectrum in vitro: Streptococcus agalactiae, Streptococcus pneumoniae (Pneumococcus), Neisseria meningitides (Meningococcus), Listeria monocytogenes, Mycoplasma pneumoniae, Chlamydia trachomatis, Ureaplasma urealyticum, Legionella pneumophila, Helicobacter (Campylobacter), Gardnerella vaginalis, Bordetella pertussis, Moraxella catarrhalis (Branhamella Catarrhalis), and Haemophilus ducreyi. Rolid Tablet 300 mg is highly concentrated in polymorphonuclear leukocytes and macrophages, achieving intracellular concentrations greater than those outside the cell. Rolid Tablet 300 mg enhances the adhesive and chemotactic functions of these cells which in the presence of infection produce phagocytosis and bacterial lysis. Rolid Tablet 300 mg also possesses intracellular bactericidal activity.
| Trade Name | Rolid Tablet 300 mg |
| Generic | Roxithromycin |
| Roxithromycin Other Names | Roxithromycin, Roxithromycine, Roxithromycinum, Roxitromicina |
| Weight | 300 mg |
| Type | Tablet |
| Formula | C41H76N2O15 |
| Weight | Average: 837.0465 Monoisotopic: 836.524569772 |
| Protein binding | 96%, mainly to alpha1-acid glycoproteins |
| Groups | Approved, Investigational, Withdrawn |
| Therapeutic Class | Macrolides |
| Manufacturer | Globe Pharmaceuticals Ltd. |
| Available Country | Bangladesh |
| Last Updated: | October 19, 2023 at 6:27 am |
Uses
Rolid Tablet 300 mg is used for the treatment of infections caused by susceptible microorganisms;
Respiratory infections like pneumonia, acute and chronic bronchitis, and bronchopneumonia
ENT infections like tonsillitis, pharyngitis, sinusitis and otitis media.
Skin infections like folliculitis, furuncles, cellulitis, carbuncles, pyoderma, impetigo and infected dermatitis.
Genital infections like urethritis, prostatitis, cervicitis and salpingitis especially if produced by Chlamydia trachomatis.
Rolid Tablet 300 mg, is a macrolide with antibacterial properties similar to erythromycin. It is active against Gram-positive bacteria like staphylococci, streptococci, listeria, corynebacteria; Gram-negative bacteria such as gonococci, Haemophilus influenzae, Haemophilus ducreyi, Legionella, campylobacter, and atypical pathogens like Mycoplasma and Chlamydia. Rolid Tablet 300 mg has been found useful in the treatment of upper and lower respiratory tract infection, otorhinolaryngological, skin, dental and genital infections. It is well tolerated by adults and children.
Rolid Tablet 300 mg is also used to associated treatment for these conditions: Lower Respiratory Tract and Lung Infections, Respiratory Tract Infections (RTI), Skin Infections, Ear, nose, and throat infections
How Rolid Tablet 300 mg works
Rolid Tablet 300 mg prevents bacterial growth by interfering with their protein synthesis. It binds to the 50S subunit of bacterial ribosomes and inhibits the translocation of peptides.
Dosage
Rolid Tablet 300 mg dosage
Adult dose: The usual dose for adults is one 300 mg tablet once daily or one 150 mg tablet twice a day for at least two days after resolution of symptoms, a normal course of therapy is between 5 and 10 days. Rolid Tablet 300 mg is best administered on empty stomach. In severe hepatic impairment the dose is 150 mg once daily.
Pediatric dose: The dose for children is 2.5 to 5 mg/kg body weight twice a day. The following general guidelines can be followed
- 6 to 11 Kg: 25 mg Rolid Tablet 300 mg 12 hourly.
- 12 to 23 Kg: 50 mg Rolid Tablet 300 mg 12 hourly.
- 24 to 40 Kg: 100 mg Rolid Tablet 300 mg 12 hourly.
A normal course of therapy is between 5 and 10 days.
Side Effects
Rolid Tablet 300 mg is well tolerated by patients of all age groups. Less than 4% of treated patients complain of side effects mainly nausea, abdominal pain, diarrhoea and hypersensitivity rash. Other side effects reported include vomiting, dizziness, headache, pruritus, dyspepsia, flatulence, tinnitus, vertigo and constipation. These are in general minor and do not necessitate withdrawal of therapy.
Toxicity
Rolid Tablet 300 mg primarily causes gastrointestinal adverse events, such as diarrhoea, nausea, abdominal pain and vomiting. Less common adverse events include headaches, rashes, abnormal liver function values and alteration in senses of smell and taste.
Precaution
Rolid Tablet 300 mg should not be used in patients with a history of hypersensitivity to the drug. In patients with hepatic diseases the dose of Rolid Tablet 300 mg should not exceed 150 mg twice a day.
Interaction
Rolid Tablet 300 mg does not have any affinity for cytochrome P-450 binding sites and thus is unlikely to produce drug interaction mediated by this enzymatic system. Rolid Tablet 300 mg shows mild interaction with theophylline though this has not been found to produce clinically relevant effects. Alteration in the pharmacokinetics of carbamazepine or warfarin has not been found. Antacids, H2- receptor antagonists and food has no effect on the absorption of Rolid Tablet 300 mg.
Elimination Route
Very rapidly absorbed and diffused into most tissues and phagocytes.
Half Life
12 hours
Pregnancy & Breastfeeding use
The safety of Rolid Tablet 300 mg in pregnancy has not been established. It appears in breast milk in small amounts and dose not produce adverse effects in the breast fed infant.
Contraindication
Rolid Tablet 300 mg should not be administered simultaneously with ergotamine or its derivatives as it may provoke arterial spasm and severe ischaemia.
Innovators Monograph
You find simplified version here Rolid Tablet 300 mg
Rolid Tablet 300 mg contains Roxithromycin see full prescribing information from innovator Rolid Tablet 300 mg Monograph, Rolid Tablet 300 mg MSDS, Rolid Tablet 300 mg FDA label
FAQ
What is Rolid Tablet 300 mg used for?
Rolid Tablet 300 mg is used to treat infections such as infections of the chest, tonsils, skin or genitals.
How safe is Rolid Tablet 300 mg?
There were no toxic effects. Rolid Tablet 300 mg should be considered as an effective and safe oral antibiotic to treat children with upper and lower respiratory tract and skin infections due to common pathogens.
How does Rolid Tablet 300 mg work?
Rolid Tablet 300 mg works by killing or stopping the growth of bacteria .
What are the common side effects of Rolid Tablet 300 mg?
The common side effects of Rolid Tablet 300 mg are;nausea, vomiting, stomach pain, diarrhoea, flatulence, loss of appetite. red or itchy skin, skin rash. headache, tiredness, dizziness, pins and needles, ringing in the ears.
Is Rolid Tablet 300 mg safe during pregnancy?
Rolid Tablet 300 mg a macrolide antibiotic, is regarded as inadvisable to use during pregnancy due to lack of safety data.
Is Rolid Tablet 300 mg safe during breastfeeding?
Rolid Tablet 300 mg is not approved for marketing in the United States by the U.S. Food and Drug Administration, but is available in other countries. Because of the low levels of Rolid Tablet 300 mg in breastmilk, it would not be expected to cause adverse effects in breastfed infants.
Can I drink alcohol with Rolid Tablet 300 mg?
Drinking alcohol while taking antibiotics can raise your risk of these harmful effects. If the label on your drug says not to drink alcohol during treatment, follow that advice.
Can I drive after taking Rolid Tablet 300 mg?
You should not drive or operate machinery if you're taking an antibiotic that makes you drowsy.
When is the best time to take Rolid Tablet 300 mg?
Rolid Tablet 300 mg should be taken at least 15 minutes before food or on an empty stomach (i.e. more than 3 hours after a meal).Rolid Tablet 300 mg works best if you take it on an empty stomach.
What happen If I missed Rolid Tablet 300 mg?
If you forget to take your dose, remember to take it as soon as possible. However, if your next dose is approaching, simply take it at the scheduled time. Do not take two doses at once as it can increase the chance of getting some unwanted side effects.
What happen if I overdose of Rolid Tablet 300 mg?
Overdose of a drug can be accidental. If you have taken more than the prescribed Rolid Tablet 300 mg tablets there is a chance of getting a harmful effect on your body’s functions. Overdose of a medicine can lead to some medical emergency.
Can Rolid Tablet 300 mg treat urine infection?
Rolid Tablet 300 mg works as an antibacterial agent by binding to the bacterial ribosome and disrupting protein synthesis. It's used for the treatment of infections related to the respiratory tract, urinary tract, and soft tissues.
What happens if I take Rolid Tablet 300 mg with food?
Taking it at the same time each day will have the best effect. It will also help you remember when to take it. Take your medicine on an empty stomach, for example, at least 15 minutes before food or at least 3 hours after food. Food can interfere with the absorption of this medicine.
How long do the effects of Rolid Tablet 300 mg last?
The effect of Rolid Tablet 300 mg tablets lasts for an average duration of 12 hours.
How long does it take for Rolid Tablet 300 mg to take effect?
You will start to feel better in 3 to 5 days after taking the Rolid Tablet 300 mg tablet. Finish your entire course of treatment, even if the condition gets better.
Can Rolid Tablet 300 mg causes diarrhoea?
Rolid Tablet 300 mg can cause diarrhoea because it may also kill the helpful bacteria in your stomach or intestine. Get emergency medical help if you experience severe diarrhoea that is watery or bloody. Call your pharmacist/doctor before taking anti-diarrhoeal medication.
Can Rolid Tablet 300 mg causes vaginal thrush?
Rolid Tablet 300 mg Tablet can cause itching and burning sensations in the vagina and may cause an abnormal discharge as well. Contact your doctor if such symptoms are experienced while using this medicine.
Can Rolid Tablet 300 mg causes mouth sores?
Rolid Tablet 300 mg can cause mouth sores that may appear while using or soon after discontinuing the use. Contact your doctor if have sores in the mouth or swelling of the lips or tongue.
What happens if I overdose on Rolid Tablet 300 mg?
Seek emergency medical attention.
