Rolitetraciclina

Rolitetraciclina Uses, Dosage, Side Effects, Food Interaction and all others data.

A pyrrolidinylmethyl tetracycline.

Trade Name Rolitetraciclina
Generic Rolitetracycline
Rolitetracycline Other Names Rolitetraciclina, Rolitetracycline, Rolitetracyclinum
Type
Formula C27H33N3O8
Weight Average: 527.5662
Monoisotopic: 527.226765047
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Rolitetraciclina
Rolitetraciclina

Uses

Rolitetraciclina is a broad-spectrum tetracycline antibiotic used in cases needing high concentrations or when oral administration is impractical.

Rolitetraciclina is a broad-spectrum antibiotic used in cases needing high concentrations or when oral administration is impractical.

How Rolitetraciclina works

Rolitetraciclina is a semisynthetic broad-spectrum tetracycline antibiotic used especially for parenteral administration in cases requiring high concentrations or when oral administration is impractical. Rolitetraciclina passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis.

Toxicity

Symptoms of overdose include anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region, skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg (I.P. in rat).

Food Interaction

  • Avoid milk and dairy products. Dairy products contain cations such as calcium which may interfere with the absorption of rolitetracycline.

Innovators Monograph

You find simplified version here Rolitetraciclina

*** Taking medicines without doctor's advice can cause long-term problems.
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