Rolofylline Uses, Dosage, Side Effects and more
Rolofylline is under clinical development by pharmaceutical company NovaCardia for the treatment of congestive heart failure.
| Trade Name | Rolofylline |
| Generic | Rolofylline |
| Rolofylline Other Names | Rolofylline |
| Type | |
| Formula | C20H28N4O2 |
| Weight | Average: 356.47 Monoisotopic: 356.221226158 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
How Rolofylline works
Rolofylline is an adenosine A1-receptor antagonist. Plasma adenosine levels are elevated in patients with heart failure and adenosine A1 receptors in the kidney mediate vasoconstriction of afferent arterioles, reabsorption of sodium and water in proximal tubules, and tubuloglomerular feedback in the juxtaglomerular apparatus. Accordingly, inhibition of these receptors would be expected to increase renal blood flow and enhance diuresis. The effects of Rolofylline on renal function are consistent with those obtained with another adenosine A1-receptor antagonist in both experimental and human heart failure.
