Rolofylline

Rolofylline Uses, Dosage, Side Effects, Food Interaction and all others data.

Rolofylline is under clinical development by pharmaceutical company NovaCardia for the treatment of congestive heart failure.

Trade Name	Rolofylline
Generic	Rolofylline
Rolofylline Other Names	Rolofylline
Type
Formula	C20H28N4O2
Weight	Average: 356.47 Monoisotopic: 356.221226158
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

How Rolofylline works

Rolofylline is an adenosine A1-receptor antagonist. Plasma adenosine levels are elevated in patients with heart failure and adenosine A1 receptors in the kidney mediate vasoconstriction of afferent arterioles, reabsorption of sodium and water in proximal tubules, and tubuloglomerular feedback in the juxtaglomerular apparatus. Accordingly, inhibition of these receptors would be expected to increase renal blood flow and enhance diuresis. The effects of Rolofylline on renal function are consistent with those obtained with another adenosine A1-receptor antagonist in both experimental and human heart failure.

Innovators Monograph

You find simplified version here Rolofylline