Roxatidine Acetate Hydrochloride Sawai

Roxatidine Acetate Hydrochloride Sawai Uses, Dosage, Side Effects, Food Interaction and all others data.

Roxatidine Acetate Hydrochloride Sawai acetate suppresses the effect of histamine on the parietal cells of the stomach (H2-receptor antagonist). This suppressive action is dose-dependent. As a result, the production and secretion, particularly of gastric acid, are reduced. Roxatidine Acetate Hydrochloride Sawai acetate has no antiandrogenic effects and does not influence drug-metabolizing enzymes in the liver.

The H2 antagonists are competitive inhibitors of histamine at the parietal cell H2 receptor. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: histamine released by ECL cells in the stomach is blocked from binding on parietal cell H2 receptors which stimulate acid secretion, and other substances that promote acid secretion (such as gastrin and acetylcholine) have a reduced effect on parietal cells when the H2 receptors are blocked.

Roxatidine Acetate Hydrochloride Sawai
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Roxatidine Acetate Hydrochloride Sawai
Generic	Roxatidine
Type
Therapeutic Class	H2 receptor antagonist
Manufacturer
Available Country	Japan
Last Updated:	September 19, 2023 at 7:00 am

Uses

For the treatment of disorders of the upper gastro intestinal region that are due to an excess of hydrochloric acid in the gastric juice, i.e. duodenal ulcers, benign gastric ulcers. Also for prophylaxis of recurrent gastric and duodenal ulcers

Dosage

Roxatidine Acetate Hydrochloride Sawai dosage

Zollinger-Ellison syndrome:75 mg bid.

Gastro-oesophageal reflux disease:75 mg bid or 150 mg at bedtime for 6-8 wk.

Premedication before anaesthesia:75 mg in the evening on the day before surgery and repeated 2 hr before induction of anaesthesia. Alternatively, 150 mg once on the night before surgery.

Peptic ulcer:150 mg at bedtime or 75 mg bid daily for 4-6 wk. Maintenance: 75 mg at bedtime.

Gastritis:75 mg once daily in the evening.

Side Effects

Occasional headache, GI disturbances, gynaecomastia, alopecia, blood dyscrasias, pancreatitis, sleep disturbances, restlessness, rarely dizziness. Hypersensitivity reactions e.g. rash and itching reported occasionally. Changes in pulse rate and transient impairment of sexual drive. Possible increase in liver enzyme activity. May reduce leucocytes and/or thrombocytes.

Precaution

Renal and hepatic impairment, pregnancy. May mask the symptoms of gastric malignancy

Interaction

May affect serum levels of protease inhibitors.

Pregnancy & Breastfeeding use

Pregnancy category is not classified. Contraindications in lactation

Contraindication

Lactation, Porphyria

Special Warning

Renal Impairment:

Zollinger-Ellison syndrome:

CrCl <20: 75 mg every 2 days.
CrCl 20-50: 75 mg at bedtime.

Gastro-oesophageal reflux disease:

CrCl <20: 75 mg every 2 days.
CrCl 20-50: 75 mg at bedtime.

Peptic ulcer:

CrCl <20: 75 mg every 2 days.
CrCl 20-50: 75 mg at bedtime.

Gastritis:

CrCl <20: 75 mg every 2 days.
CrCl 20-50: 75 mg at bedtime.

Innovators Monograph

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FAQ

What is Roxatidine Acetate Hydrochloride Sawai used for?

Roxatidine Acetate Hydrochloride Sawai is used to treat gastric ulcers, Zollinger Ellison syndrome, erosive esophagitis, gastro-oesophageal reflux disease, and gastritis.

How does Roxatidine Acetate Hydrochloride Sawai work?

Roxatidine Acetate Hydrochloride Sawai blocks histamine secretion. It curbs the production of acid by parietal cells and digestive acids. This drug prevents the histamine from binding on parietal cell H2 receptors, thereby controlling the symptoms of gastrointestinal disorders.

What are the common side effects of Roxatidine Acetate Hydrochloride Sawai?

The common side effects of Roxatidine Acetate Hydrochloride Sawai are skin Rash, gastrointestinal Constipation, diarrhea, nausea and gastrointestinal disturbances. Central Nervous System: Weakness, headache, dizziness, restlessness and drowsiness.

Is Roxatidine Acetate Hydrochloride Sawai safe during pregnancy?

Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.Use is recommended only if clearly needed and the benefit outweighs the risk.

Is Roxatidine Acetate Hydrochloride Sawai safe during breastfeeding?

This drug is known to increase prolactin levels. There are no data on galactorrhea and adverse effects with breastfeeding.Caution is recommended.

Can I take Roxatidine Acetate Hydrochloride Sawai empty stomach?

Roxatidine Acetate Hydrochloride Sawai may be taken with or without food. It can be taken once daily before bedtime or twice daily in the morning and before bedtime, as recommended.

How long does it take for Roxatidine Acetate Hydrochloride Sawai to start work?

After taking Roxatidine Acetate Hydrochloride Sawai orally, the effect occurs within one hour. The maximum effect is generally reached within one to three hours of taking it. However, it depends upon the dose. The action of the medicine lasts for about 10 to 12 hours.

Can I take alcohol with Roxatidine Acetate Hydrochloride Sawai?

Alcohol does not interfere with the working of Roxatidine Acetate Hydrochloride Sawai. But, you should avoid taking alcohol as it will further damage the stomach, delaying your recovery.

Is Roxatidine Acetate Hydrochloride Sawai safe for long-term use?

There is limited data available on whether Roxatidine Acetate Hydrochloride Sawai can be used for a long term or not, but it is a relatively safe medicine. You should take it for the duration advised by your doctor. Do not take over-the-counter Roxatidine for longer than 2 weeks unless advised by your doctor.

What is the effect of Roxatidine Acetate Hydrochloride Sawai on the Kidneys?

Roxatidine Acetate Hydrochloride Sawai may have mild side effects on the kidneys.

What is the effect of Roxatidine Acetate Hydrochloride Sawai on the Liver?

Very few cases of side effects of Roxatidine Acetate Hydrochloride Sawai on the liver have been reported.

What is the effect of Roxatidine Acetate Hydrochloride Sawai on the Heart?

Roxatidine Acetate Hydrochloride Sawai is completely safe for the heart.

Is Roxatidine Acetate Hydrochloride Sawai safe?

Roxatidine Acetate Hydrochloride Sawai is safe as it does not bear any side effects.

Can I drive after taking Roxatidine Acetate Hydrochloride Sawai?

Roxatidine Acetate Hydrochloride Sawai does not cause dizziness or sleep, so you can drive a vehicle or operate machinery also.

Who should not take Roxatidine Acetate Hydrochloride Sawai?

Contraindicated in patients with absence of urination, gastric malignancy and hypersensitivity.

What is the dosage of Roxatidine Acetate Hydrochloride Sawai?

The recommended dose of 150mg/day.

What happen if I overdose on Roxatidine Acetate Hydrochloride Sawai?

A wide range of signs and symptoms can occur when a person overdoses, and everyone responds differently. Signs and symptoms depend on a variety of factors including: