RPDGF-BB

RPDGF-BB Uses, Dosage, Side Effects, Food Interaction and all others data.

RPDGF-BB is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. RPDGF-BB has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together by disulfide bonds.

Used for the topical treatment of skin ulcers, Regranex has a biological activity similar to that of endogenous platelet-derived growth factor, which includes promoting the chemotactic recruitment and proliferation of cells involved in wound repair and enhancing the formation of granulation tissue.

RPDGF-BB
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Trade Name	RPDGF-BB
Availability	Prescription only
Generic	Becaplermin
Becaplermin Other Names	Becaplermin, PDGF-2, PDGF-BB, PDGFB, Platelet-derived growth factor BB, recombinant, Platelet-derived growth factor beta polypeptide, Recombinant platelet-derived growth factor BB, rhPDGF-BB, rPDGF-BB, SH-POLYPEPTIDE-59
Related Drugs	Iodosorb, cadexomer iodine topical
Type
Formula	C₅₃₂H₈₉₂N₁₆₂O₁₅₃S₉
Weight	12294.4 Da
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

RPDGF-BB is a recombinant form of human platelet-derived growth factor used to treat ulcers due to diabetic neuropathy in the lower extremities when there is adequate blood supply to the area.

For topical treatment of skin ulcers (from diabetes)

RPDGF-BB is also used to associated treatment for these conditions: Skin Ulcer

How RPDGF-BB works

Binds to the beta platelet-derived growth factor (PDGF) receptor, a tyrosine kinase receptor. PDGF is known to exist as a dimer, and activates its signaling pathway by a ligand induced receptor dimerization and autophosphorylation. PDGF receptors also contain many auto-phosphorylation sites, which serve to mediate binding of SH2 sites and subsequently signal corresponding pathways. There are five different isoforms of PDGF that activate through two different receptors (alpha and beta).