(RS)-Lormetazepam

(RS)-Lormetazepam Uses, Dosage, Side Effects, Food Interaction and all others data.

Lormatazepam is an orally available benzodiazepine used in the UK for the treatment of short-term insomnia . It is marketed by Auden Mckenzie (Pharma Division) in 0.5 and 1 mg tablet formulations.

(RS)-Lormetazepam is a benzodiazepine which reduces central nervous system (CNS) activity . It produces anxiolytic, muscle relaxant, sedative and hypnotic effects. Because it is a short-acting benzodiapine, it does not produce significant sedation after waking.

Trade Name (RS)-Lormetazepam
Generic Lormetazepam
Lormetazepam Other Names (RS)-Lormetazepam, Lormetazepam, Methyllorazepam, N-Methyllorazepam
Type
Formula C16H12Cl2N2O2
Weight Average: 335.185
Monoisotopic: 334.027583052
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
(RS)-Lormetazepam
(RS)-Lormetazepam

Uses

(RS)-Lormetazepam is a benzodiazepine indicated in the treatment of anxiety and the induction of anesthesia.

For the treatment of short-term insomnia

(RS)-Lormetazepam is also used to associated treatment for these conditions: Severe Insomnia, Sleep Disorder, Acute Anxiety

How (RS)-Lormetazepam works

(RS)-Lormetazepam, as a benzodiazepine, binds to the regulatory site between the α and γ subunits of γ-aminobutryic acid (GABA) A receptors with γ2 and α1, α2, α3, or α5 subunits . This facilitates the opening of the chloride channel allowing chloride ions to flow into the neuron resulting in hyperpolarization. Hyperpolarized neurons require greater simulation to reach their action potential threshold. The general inhibitory effect on neuronal depolarization produces the effects of lormetazepam.

Toxicity

The primary manifestation of overdosage ranges from drowsiness to coma and symptoms may include ataxia, hypotension, hypotonia, respiratory depression which may lead to death .

Experimental LD50 values are as follows : Mouse - 780 mg/kg (intraperitoneal), 1790 mg/kg (oral), 10000 mg/kg (subcutaneous). Rat - 6250 mg/kg (intraperitoneal), 10000 mg/kg (oral), 10000 mg/kg (intraperitoneal).

Half Life

The terminal phase half life is 11 h .

Innovators Monograph

You find simplified version here (RS)-Lormetazepam

*** Taking medicines without doctor's advice can cause long-term problems.
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