Rubab

Rubab Uses, Dosage, Side Effects, Food Interaction and all others data.

This oral solution exerts an anti-inflammatory action in the cases of inflammatory infections on the mucosa of the mouth or throat. Its analgesic properties allow to rapidly suppressing pains and the sensitivity of the tissue submitted to inflammatory processes. This oral solution allows that, after a short time, mucosa resume their normal physiological functions, without exerting any harmful action on the tissues. It's use is easy and painless. It is well tolerated by individuals sensitive to iodine.

Rubab
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Rubab
Generic	Rhubarb Extract + Salicylic Acid
Weight	5%+1%
Type	Oral Solution
Therapeutic Class	Oral preparations
Manufacturer	Incepta Pharmaceuticals Limited
Available Country	Bangladesh
Last Updated:	September 19, 2023 at 7:00 am

Uses

Per ml of solution containing 50 mg rhubarb extract and 10 mg salicylic acid

This oral solution is used for the treatment of acute and chronic inflammations of the mucosas of the mouth and throat (Aphthous ulcer, gingivitis, periodontitis and denture irritation).

Rubab is also used to associated treatment for these conditions: Acne, Actinic Keratosis (AK), Alopecia Areata (AA), Atopic Dermatitis (AD), Blackheads, Chronic Eczema, Chronic cutaneous lupus erythematosus, Corns, Dandruff, Dermatitis, Contact, Dermatitis, Eczematous, Dermatitis, Eczematous of the scalp, Discoid Lupus Erythematosus (DLE), Foot Callus, Fungal skin infection, Furuncle, Hand Eczema, Hyperkeratosis, Hyperkeratosis follicularis et parafollicularis, Infections, Fungal, Infections, Fungal of the Skin Folds, Infections, Fungal of the face, Infections, Fungal of the feet, Infections, Fungal of the hand, Keratosis Palmaris et Plantaris, Lichen, Lichen Plano-Pilaris, Lichen Planus (LP), Lichen simplex chronicus, Molluscum Contagiosum, Musculoskeletal Pain, Neurodermatitis, Palmo-Plantar Pustulosis, Plantar Warts, Pruritus, Psoriasis, Psoriasis Vulgaris (Plaque Psoriasis), Psoriasis of the scalp, Rash, Ringworm of the Skin, Ringworm of the scalp, Seborrheic Dermatitis, Seborrhoeic Dermatitis of the Scalp, Skin Infections, Bacterial, Verrucous Psoriasis, Warts, Calluses, Corticosteroid-responsive dermatoses, Keratinization disorders, Scaling, Scaling of skin, Scalp seborrhea, Superficial Fungal skin infection, Keratolysis

How Rubab works

Salicylic acid directly irreversibly inhibits COX-1 and COX-2 to decrease conversion of arachidonic acid to precursors of prostaglandins and thromboxanes. Salicylate's use in rheumatic diseases is due to it's analgesic and anti-inflammatory activity. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Salicylic acid allows cells of the epidermis to more readily slough off. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid competitively inhibits oxidation of uridine-5-diphosphoglucose (UDPG) with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. It also competitively inhibits the transferring of the glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to a phenolic acceptor. Inhibition of mucopoly saccharide synthesis is likely responsible for the slowing of wound healing with salicylates.

Dosage

Rubab dosage

Adults (including the elderly): To be applied to the inflamed oral mucosa (after removing any dentures) three or four times daily using the brush provided. Avoid rinsing the mouth or eating for 15 minutes after application. Always keep the cap closed immediately after every use.

Children: Not recommended below the age of 12 years

Side Effects

A transient local burning sensation at the site of application occurs very commonly. Temporary discoloration of teeth or oral mucosa has been described commonly following administration of oral solution.

Toxicity

Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.

Precaution

Each bottle of oral solution should be used by only one person.

Interaction

There are no known drug interactions and none well documented.

Volume of Distribution

The volume of distribution is about 170 mL/kg of body weight.

Elimination Route

About 10% is excreted unchanged in the urine.

Pregnancy & Breastfeeding use

Pregnancy: Animal studies are insufficient with respect to effects on pregnancy and/or embryonal / foetal development. The potential risk for human is unknown. Caution should be exercised when prescribing to pregnant women.

Lactation: Anthranoid glycosides derived from rhubarb may be excreted in breast milk. However, at therapeutic doses of oral solution, it is not known whether these, or salicylic acid are excreted in breast milk. A decision on whether to continue breast feeding or to continue therapy with oral solution should be made taking into account the benefit of breast-feeding to the child and benefit of oral solution therapy to the women.

Contraindication

Hypersensitivity to any of the constituents.

Special Warning

Salicylic Acid is used in children over 2 years.

Acute Overdose

Overdose associated with local application is unlikely, although the extent of systemic absorption of salicylic acid and anthranoid derivatives are not known. Systemic overdose following ingestion might lead to abdominal cramping, diarrhoea and possibly salicylism (presenting as hyperventilation, tinnitus, deafness, vasodilation, sweating).