Rubidium chloride Rb-82
Rubidium chloride Rb-82 Uses, Dosage, Side Effects, Food Interaction and all others data.
Rubidium chloride Rb-82 injection is a sterile nonpyrogenic solutions of rubidium Rb 82 chloride. It is indicated for Positron Emission Tomography (PET) imaging of the myocardium under rest or pharmacologic stress conditions to evaluate regional myocardial perfusion in adult patients with suspected or existing coronary artery disease.
In human studies, myocardial activity was noted within the first minute after peripheral intravenous injection of Rb-82. When areas of infarction or ischemia are present in the myocardium, they are visualized within 2-7 minutes after injection as photon-deficient, or “cold”, areas on the myocardial scan.In patients with reduced cardiac function, transit of the injected dose from the peripheral infusion site to the myocardium may be delayedBlood flow brings Rb-82 to all areas of the body during the first pass of circulation. Accordingly, visible uptake is also observed in other highly vascularized organs, such as the kidneys, liver, spleen and lungs.
| Trade Name | Rubidium chloride Rb-82 |
| Generic | Rubidium Rb-82 |
| Rubidium Rb-82 Other Names | Rubidium chloride Rb-82 |
| Type | |
| Formula | Rb |
| Weight | Average: 81.9177 Monoisotopic: 81.917659111 |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Rubidium chloride Rb-82 is a radiopharmaceutical diagnostic agent used for Positron Emission Tomography (PET) imaging of the myocardium to evaluate regional myocardial perfusion in adult patients with suspected or existing coronary artery disease.
Rubidium Rb 82 chloride injection is indicated for Positron Emission Tomography (PET) imaging of the myocardium under rest or pharmacologic stress conditions to evaluate regional myocardial perfusion in adult patients with suspected or existing coronary artery disease.
Rubidium chloride Rb-82 is also used to associated treatment for these conditions: Coronary Artery Disease (CAD)
How Rubidium chloride Rb-82 works
Rb-82 is analogous to potassium ion (K+) in its biochemical behavior and is rapidly extracted by the myocardium proportional to the blood flow. Rb+ participates in the sodium-potassium (Na+/K+) ion exchange pumps that are present in cell membranes. The intracellular uptake of Rb-82 requires maintenance of ionic gradient across cell membranes. Rb-82 radioactivity is increased in viable myocardium reflecting intracellular retention, while the tracer is cleared rapidly from necrotic or infarcted tissue.
Food Interaction
No interactions found.Half Life
1.27 minutes
Elimination Route
It is rapidly extracted by the myocardium proportional to blood flow.
Innovators Monograph
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