Rui Pa Ming

Uses

Rui Pa Ming is an immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis.

For the prophylaxis of organ rejection in patients receiving renal transplants.

Rui Pa Ming is also used to associated treatment for these conditions: Chordomas, Graft Versus Host Disease (GVHD), Heart Transplant Rejection, Liver Transplant Rejection, Lung Transplant Rejection, Lymphangioleiomyomatosis, Renal Angiomyolipomas, Moderate renal transplant rejection

How Rui Pa Ming works

Rui Pa Ming inhibits T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (Interleukin IL-2, IL-4, and IL-15) stimulation by a mechanism that is distinct from that of other immunosuppressants. Rui Pa Ming also inhibits antibody production. In cells, sirolimus binds to the immunophilin, FK Binding Protein-12 (FKBP-12), to generate an immunosuppressive complex. The sirolimus:FKBP-12 complex has no effect on calcineurin activity. This complex binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This inhibition suppresses cytokine-driven T-cell proliferation, inhibiting the progression from the G1 to the S phase of the cell cycle.

Food Interaction

• Avoid grapefruit products. Grapefruit inhibits the CYP3A4 metabolism of sirolimus and increases its serum concentration.
• Exercise caution with St. John's Wort. This herb induces CYP3A4 and P-gp; thus it may reduce sirolimus serum concentrations.
• Take with or without food. Take consistently with regard to food.

[Moderate] ADJUST DOSING INTERVAL: Consumption of food can decrease the rate and extent of gastrointestinal absorption of sirolimus.

Also, the consumption of grapefruit juice may result in increased sirolimus trough concentrations.

MANAGEMENT: Experts recommend that this drug be taken either at least one hour prior to eating or consistently with or without food to avoid variations in sirolimus blood levels.

The manufacturer recommends against using grapefruit juice for dilution of sirolimus doses.

Patients should be monitored for clinical and laboratory evidence of altered immunosuppressant effects.

Rui Pa Ming Cholesterol interaction

[Moderate] The use of sirolimus may increase serum cholesterol and triglycerides.

Care should be taken when prescribing this agent to hyperlipidemic patients.

It is recommended to assess the risk

It is recommended to monitor patients regularly for elevated lipids.

Rui Pa Ming Drug Interaction

Moderate: mycophenolate mofetil, loratadine, losartan, insulin glargine, mycophenolic acidUnknown: aspirin, aspirin, sulfamethoxazole / trimethoprim, carvedilol, apixaban, tamsulosin, furosemide, metoprolol, tacrolimus, pantoprazole, valganciclovir, cyanocobalamin, ergocalciferol, cholecalciferol, cetirizine

Rui Pa Ming Disease Interaction

Major: infections, PMLModerate: angioedema, hyperlipidemia, liver disease, liver transplantation, lung dysfunction, lung transplant, renal dysfunction

Half Life

57-63 hours

Innovators Monograph

You find simplified version here Rui Pa Ming