S-8510

S-8510 Uses, Dosage, Side Effects, Food Interaction and all others data.

S-8510 / SB-737552 is a BZD inverse agonist investigated for the treatment of Alzheimer’s disease and mild to moderate senile dementia. It was being codeveloped by Shionogi and GlaxoSmithKline.

Trade Name S-8510
Generic S-8510
Type
Formula C12H10N4O2
Weight Average: 242.238
Monoisotopic: 242.080375578
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
S-8510
S-8510

Uses

Investigated for use/treatment in alzheimer's disease and dementia.

How S-8510 works

S-8510 is a BZD partial inverse agonist to the BZD site on the GABA-A receptors in the central nervous system. As an inverse agonist (which as a group elicit CNS effects such as insomnia, agitation, and proconvulsant behaviors), S-8510 functions as a negative modulator of the GABA-A receptor. S-8510, however, is a partial inverse agonist, which means it has a lower affinity for the BZD binding site than do full agonists, and studies in animals have shown that the drug does not induce convulsions or anxiety.

Innovators Monograph

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