(S)-ornithine
(S)-ornithine Uses, Dosage, Side Effects, Food Interaction and all others data.
Produced during the urea cycle, ornithine is an amino acid produced from the splitting off of urea from arginine. L-(S)-ornithine allows for the disposal of excess nitrogen and acts as a precursor of citrulline and arginine.
A non-essential and nonprotein amino acid, ornithine is critical for the production of the body's proteins, enzymes and muscle tissue. (S)-ornithine plays a central role in the urea cycle and is important for the disposal of excess nitrogen (ammonia). (S)-ornithine is the starting point for the synthesis of many polyamines such as putrescine and spermine. (S)-ornithine supplements are claimed to enhance the release of growth hormone and to burn excess body fat. (S)-ornithine is necessary for proper immune function and good liver function.
| Trade Name | (S)-ornithine |
| Generic | Ornithine |
| Ornithine Other Names | (S)-ornithine, L-Ornithine, levo-ornithine, Ornithine, Ornithinum, Ornitina |
| Type | |
| Formula | C5H12N2O2 |
| Weight | Average: 132.161 Monoisotopic: 132.089877638 |
| Groups | Approved, Nutraceutical |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
(S)-ornithine is an amino acid commonly found as a component in total parenteral nutrition.
Used for nutritional supplementation, also for treating dietary shortage or imbalance. It has been claimed that ornithine improves athletic performance, has anabolic effects, has wound-healing effects, and is immuno-enhancing.
(S)-ornithine is also used to associated treatment for these conditions: Hepatic Encephalopathy (HE), Amino acid supplementation
How (S)-ornithine works
L-(S)-ornithine is metabolised to L-arginine. L-arginine stimulates the pituitary release of growth hormone. Burns or other injuries affect the state of L-arginine in tissues throughout the body. As De novo synthesis of L-arginine during these conditions is usually not sufficient for normal immune function, nor for normal protein synthesis, L-ornithine may have immunomodulatory and wound-healing activities under these conditions (by virtue of its metabolism to L-arginine).
Toxicity
Oral, rat LD50 = 10000 mg/kg
Food Interaction
No interactions found.Elimination Route
Absorbed from the small intestine via a sodium-dependent active transport process
Innovators Monograph
You find simplified version here (S)-ornithine
