Saizen Liquid
Saizen Liquid Uses, Dosage, Side Effects, Food Interaction and all others data.
Saizen Liquid is a synthetic human growth hormone of recombinant DNA origin. It stimulates skeletal and soft tissue growth by promoting cell division, amino acid uptake and protein synthesis. It also possesses both insulin-like and diabetogenic effects.
| Trade Name | Saizen Liquid |
| Availability | Prescription only |
| Generic | Somatropin |
| Related Drugs | megestrol, dronabinol, Marinol, oxandrolone, Megace, Genotropin, Norditropin, glutamine, Skytrofa, Humatrope |
| Type | |
| Therapeutic Class | Drugs for Growth failure |
| Manufacturer | |
| Available Country | Switzerland |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Children’s growth disorders, Chronic renal failure, Growth hormone deficiency, HIV-associated wasting or cachexia, Intrauterine growth retardation, Prader Willi syndrome, Severe idiopathic short stature, Short bowel syndrome, Sjogren’s syndrome
Dosage
Saizen Liquid dosage
Children with short stature homeobox-containing (SHOX) deficiency:
- Child: 50 mcg/kg/day may be used.
Growth retardation due to chronic renal insufficiency, Turner's syndrome:
- Child: 45-50 mcg/kg or 1.4 mg/m2 daily.
Growth retardation in children who were born small for gestational age, Prader-Will syndrome:
- Child: 35 mcg/kg or 1 mg/m2 daily. Max: 2.7 mg daily.
Growth hormone deficiency:
- Adult: Initially, 6 mcg/kg daily. May increase gradually according to patient response. Max: 12.5 mcg/kg/day. Reassess 9 mth after starting treatment.
- Child: 25-35 mcg/kg daily. Reassess 9 mth after starting treatment.
- Elderly: Lower doses may be required.
Short bowel syndrome:
- Adult: 100 mcg/kg/day for 4 wk. Max: 8 mg/day.
HIV-associated wasting or cachexia:
- Adult: 0.1 mg/kg daily at bedtime. May be taken on alternate days for patients at increased risk of adverse effects. Max: 6 mg/day.
Side Effects
Hypothyroidism, peripheral oedema; headache; muscle and joint pain; benign intracranial hypertension. Loss of glycaemic control in diabetics.
Precaution
Monitor thyroid function; benign intracranial hypertension. DM; may require dose reduction in insulin. Pregnancy. Discontinue treatment if there is evidence of tumour growth. Monitoring in patients with scoliosis is recommended due to risk of progression of scoliosis.
Interaction
High doses of corticosteroid may inhibit growth-promoting effects of somatropin.
Saizen Liquid Drug Interaction
Moderate: testosterone, tamsulosin, atorvastatin, omeprazole, montelukast, carbamazepine, alprazolam, ondansetronUnknown: aspirin, amphetamine / dextroamphetamine, lorazepam, multivitamin, dehydroepiandrosterone, heparin, levetiracetam, vitamin a topical, bioflavonoids, sotalol, levothyroxine, cholecalciferol
Saizen Liquid Disease Interaction
Major: active malignancy, acute critical illness, diabetic retinopathy, Prader-Willi SyndromeModerate: diabetes, hypothyroidism, intracranial hypertension, scoliosis, Turner syndrome
Pregnancy & Breastfeeding use
Pregnancy Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Contraindication
Acute critical illness due to heart or abdominal surgery, multiple accidental trauma or respiratory failure; active neoplasms, proliferative or preproliferative diabetic retinopathy; lactation; patients with closed epiphyses. Intracranial lesions. Patients with Prader-Willi syndrome who are severely obese or have severe respiratory impairment.
Storage Condition
Store at 2-8° C.
Innovators Monograph
You find simplified version here Saizen Liquid
FAQ
What is Saizen Liquid used for?
Saizen Liquid is used to treat growth failure in children and adults who lack natural growth hormone. This includes people with short stature due to Noonan syndrome, Turner syndrome, Prader-Willi syndrome, short stature at birth with no catch-up growth, and other causes.
How safe is Saizen Liquid?
Saizen Liquid may contain an ingredient that can cause serious side effects or death in very young or premature babies. Do not give this medicine to a child without medical advice.
How does Saizen Liquid work?
Saizen Liquid works by stimulating metabolic processes in cells to activate metabolism. It stimulates the liver to make an insulin-like protein that produces cartilage cells. This plays a part in bone and organ growth, as well as muscle protein synthesis.
What are the common side effects of Saizen Liquid?
The common side effects of Saizen Liquid are include:
Headache, nausea, vomiting, fatigue, muscle pain, or weakness.
Is Saizen Liquid safe during breastfeeding?
Saizen Liquid during pregnancy does not increase the risk of birth defects above the baseline rate. Use is not recommended unless clearly needed.
Is Saizen Liquid safe during pregnancy?
Following subcutaneous administration of radiolabeled medication in animal studies, radioactivity was transferred to milk reaching four times the concentration found in maternal plasma.
Can I drink alcohol with Saizen Liquid?
Avoid drinking alcohol if you have short bowel syndrome. Alcohol can irritate your stomach and could make your condition worse.
How much Saizen Liquid should I take a day?
The recommended dose of Saizen Liquid in adults is 0.15 mg to 0.3 mg per day up to a maximum of 1.33 mg per day.
What time of day should I take Saizen Liquid?
Saizen Liquid be taken several hours after the last meal of the day.
How long does it take for Saizen Liquid to work?
If this medicine is used for weight loss/muscle wasting, it may take up to 2 weeks to notice the effects of the drug. Do not use more of this medication than prescribed or use it more often since the risk of side effects will be increased.
What does Saizen Liquid do in the body?
Saizen Liquid is a major participant in control of several complex physiologic processes, including growth and metabolism.
How tall does Saizen Liquid make me?
Medications, such as Saizen Liquid, may eventually add 4 inches, or 10 centimeters, to adult height.
Who should not take Saizen Liquid?
You should not use Saizen Liquid if you have cancer, diabetic retinopathy, or if you are being treated for Prader-Willi syndrome and you are overweight or have severe breathing problems.
How should I use Saizen Liquid?
Your dose and Saizen Liquid of Saizen Liquid and how often you use it will depend on the condition you are treating. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Saizen Liquid is injected into a muscle or under the skin. A healthcare provider can teach you how to properly use the medication by yourse.
How long should I take Saizen Liquid?
We will advise you to continue treatment for at least six to nine months.
Where do I inject Saizen Liquid?
This medicine is for injection under the skin or into a muscle. It is usually given by a health care professional in a hospital or clinic setting.
What happen If I miss Saizen Liquid?
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Just take the next dose at your regular time.
What happen If I overdose of Saizen Liquid?
Overdose can cause tremors or shaking, cold sweats, increased hunger, headache, drowsiness, weakness, dizziness, fast heartbeat, and nausea. Long-term overdose may cause excessive growth.
Does Saizen Liquid build muscle?
Saizen Liquid helps to build muscle mass, boost metabolism, and burn fat. Saizen Liquid is also said to benefit the quality and appearance of the skin.
