Salazopyrine Zetpil, Zetpillen
Salazopyrine Zetpil, Zetpillen Uses, Dosage, Side Effects, Food Interaction and all others data.
The mode of action of Salazopyrine Zetpil, Zetpillen is still under investigation, but may be related to the anti inflammatory and/or immunomodulatory properties that have been observed in animal and in vitro models, to its affinity for connective tissue, and/or to the relatively high concentration it reaches in serous fluids, the liver and intestinal walls, as demonstrated in autoradiographic studies in animals. In ulcerative colitis, clinical studies utilizing rectal administration of Salazopyrine Zetpil, Zetpillen, Sulfapyridine and 5-Aminosalyclic Acid have indicated that the major therapeutic action may reside in the 5-Aminosalyclic Acid moiety. The relative contribution of the parent drug and the major metabolites in rheumatoid arthritis is unknown.
Salazopyrine Zetpil, Zetpillen is an anti-inflammatory indicated for the treatment of ulcerative colitis and rheumatoid arthritis.
Trade Name | Salazopyrine Zetpil, Zetpillen |
Availability | Prescription only |
Generic | Sulfasalazine |
Sulfasalazine Other Names | Azopyrin, Salazosulfapiridina, Salazosulfapyridine, Salazosulfapyridinum, Salicylazosulfapyridine, Sulfasalazin, Sulfasalazina, Sulfasalazine, Sulfasalazinum |
Related Drugs | Lialda, Pentasa, Apriso, Azulfidine, Asacol, Canasa, Delzicol, Asacol HD, Dipentum, Rowasa |
Type | |
Formula | C18H14N4O5S |
Weight | Average: 398.393 Monoisotopic: 398.068490268 |
Groups | Approved |
Therapeutic Class | Drugs for Irritable Bowel Syndrome, Drugs used for Rheumatoid Arthritis, Ulcerative Colitis |
Manufacturer | |
Available Country | Netherlands |
Last Updated: | September 19, 2023 at 7:00 am |
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Uses
Salazopyrine Zetpil, Zetpillen is used for:
- Rheumatoid arthritis & Juvenile arthritis: In the treatment of patients with rheumatoid arthritis and pediatiric patients with polyarticular-course juvenile rheumatoid arthritis, who have responded inadequately to salicylates or other non-steroidal anti-inflammatory drugs (NSAIDs).
- Ulcerative colitis and Crohn's Disease: As adjunct in the treatment of ulcerative colitis with the usual supportive and dietary measures. In the treatment of active Crohn's disease, especially in patients with colonic involvement.
Salazopyrine Zetpil, Zetpillen is also used to associated treatment for these conditions: Crohn's Disease (CD), Polyarticular juvenile rheumatoid arthritis, chronic or unspecified, Proctitis, Rheumatoid Arthritis, Severe Ulcerative Colitis, Mild Ulcerative Colitis, Moderate Ulcerative colitis
How Salazopyrine Zetpil, Zetpillen works
The mode of action of Salazopyrine Zetpil, Zetpillen or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), is still under investigation, but may be related to the anti-inflammatory and/or immunomodulatory properties that have been observed in animal and in vitro models, to its affinity for connective tissue, and/or to the relatively high concentration it reaches in serous fluids, the liver and intestinal walls, as demonstrated in autoradiographic studies in animals. In ulcerative colitis, clinical studies utilizing rectal administration of Salazopyrine Zetpil, Zetpillen, SP and 5-ASA have indicated that the major therapeutic action may reside in the 5-ASA moiety. The relative contribution of the parent drug and the major metabolites in rheumatoid arthritis is unknown.
Dosage
Salazopyrine Zetpil, Zetpillen dosage
The dosage of Salazopyrine Zetpil, Zetpillen tablets should be individually adjusted according to the patient's tolerance and response to the treatment and taken in evenly divided doses preferably after meals.
Adult dose for crohn’s disease: 500 mg orally 2 to 4 times a day with food.
Pediatric use (6 years or older) for Ulcerative Colitis: The initial dose 40 to 60 mg/kg/day orally divided into 3 to 6 doses.
Adultdose for rheumatoid arthritis: 2 g daily in two evenly divided doses. It is advisable to initiate therapy with a lower dosage e.g. 0.5 to 1.0 g daily, to reduce possible gastrointestinal intolerance. A suggested dosing schedule is given bellow:
- First week: One tablet in theevening
- Secondweek: One tabletin the morning &One tabletin the evening
- Thirdweek:One tabletin the morning & two tabletin the evening
- Forthweek: Two tabletin the morning &two tabletin the evening
In case of rheumatoid arthritis 6 years or older: initial dose 10 mg/kg/day orally in 2 equally divided doses.
Juvenile rheumatoid arthritis-polyarticular course: Children 6 years of age and older: 30 to 50 mg/kg/day in two evenly divided doses. Typically the maximum dose is 2 g per day.
For other indications:
Initial therapy:
- Adults: 3 to 4 g daily in divided doses with dosage intervals not exceeding eight hours. It may be advisable to initiate therapy with a lower dosage e.g. 1 to 2 g daily to reduce possible gastrointestinal intolerance.
- Children 6 years of age and older: 40 to 60 mg/kg/day in to 3 to 6 divided doses.
Maintenance therapy:
- Adults: 2 g daily.
- Children 6 years of age and older: 30 mg/kg/day in 4 divided doses.
Side Effects
The common adverse reactions are anorexia, headache, nausea, vomiting, gastric distress, dyspepsia, abdominal pain, dizziness, apparently reversible oligospermia etc.
Precaution
Hepatic/renal impairment, G6PD deficiency, allergic bronchial asthma, lactation.
Interaction
Reduced absorption of folic acid and digoxin has been reported when those agents were administered concomitantly with sulfasalazine.
Food Interaction
- Drink plenty of fluids. Inadequate fluid intake is associated with crystalluria and stone formation.
- Take with food.
Salazopyrine Zetpil, Zetpillen Drug Interaction
Moderate: celecoxibUnknown: aspirin, diphenhydramine, duloxetine, etanercept, omega-3 polyunsaturated fatty acids, cyclobenzaprine, adalimumab, pregabalin, metoprolol, esomeprazole, acetaminophen / hydrocodone, hydroxychloroquine, montelukast, levothyroxine, acetaminophen, cyanocobalamin, ascorbic acid, cholecalciferol, cetirizine
Salazopyrine Zetpil, Zetpillen Disease Interaction
Major: colitis, intestinal obstruction, urinary obstruction, hematologic toxicity, hypersensitivity reactions, liver disease, porphyria, renal dysfunctionModerate: renal dysfunction, folate deficiency, G6PD deficiency, crystalluria
Volume of Distribution
- 7.5 ± 1.6 L
Half Life
5-10 hours
Clearance
- 1 L/h [IV administration]
Elimination Route
The majority of 5-ASA stays within the colonic lumen and is excreted as 5-ASA and acetyl-5-ASA with the feces.
Pregnancy & Breastfeeding use
Use in pregnancy: Pregnancy category B. This drug should be used during pregnancy only if clearly needed.
Use in lactation: Caution should be exercised when sulfasalazine is administered to a nursing mother.
Contraindication
Hypersensitivity to Salazopyrine Zetpil, Zetpillen, its metabolites, sulfonamides or salicylates, patients with intestinal or urinary obstruction and porphyria.
Storage Condition
Store in a cool and dry place, protected from light.
Innovators Monograph
You find simplified version here Salazopyrine Zetpil, Zetpillen
Salazopyrine Zetpil, Zetpillen contains Sulfasalazine see full prescribing information from innovator Salazopyrine Zetpil, Zetpillen Monograph, Salazopyrine Zetpil, Zetpillen MSDS, Salazopyrine Zetpil, Zetpillen FDA label
FAQ
What is Salazopyrine Zetpil, Zetpillen used for?
Salazopyrine Zetpil, Zetpillen is used to treat bowel inflammation, diarrhea, rectal bleeding, and abdominal pain in patients with ulcerative colitis, a condition in which the bowel is inflamed.
How safe is Salazopyrine Zetpil, Zetpillen?
Salazopyrine Zetpil, Zetpillen may cause reversible male infertility, but it is entirely safe for use during pregnancy and lactation. Overall, Salazopyrine Zetpil, Zetpillen has a long and impressive safety record, provided the drug is used with an awareness and appreciation of its potential pitfalls.
How does Salazopyrine Zetpil, Zetpillen work?
Salazopyrine Zetpil, Zetpillen is an anti-inflammatory drug.Salazopyrine Zetpil, Zetpillen believed that it affects your immune system and decreases inflammation. Salazopyrine Zetpil, Zetpillen work by locally in the colon to decrease inflammation. It also works throughout the body by inhibiting the formation of a chemical known as prostaglandins.
What are the common side effects of Salazopyrine Zetpil, Zetpillen?
The more common side effects of Salazopyrine Zetpil, Zetpillen are include:
- decreased appetite
- headache
- nausea
- vomiting
- stomach upset and pain
- rash
- itching
- decreased sperm count (only while taking the medication)
- dizziness
Is Salazopyrine Zetpil, Zetpillen safe during pregnancy?
Salazopyrine Zetpil, Zetpillen does not increase the risk of any complications of pregnancy or the risk of birth defects.
Is Salazopyrine Zetpil, Zetpillen safe during breastfeeding?
Salazopyrine Zetpil, Zetpillen is considered safe to use while you are breastfeeding, unless the baby is premature or at risk of jaundice.
Can I drink alcohol with Salazopyrine Zetpil, Zetpillen?
There's no particular reason to avoid alcohol while on Salazopyrine Zetpil, Zetpillen. However, it's recommended that people try to keep well within the recommended limits for alcohol. This limit is 14 units a week for women and men.
How quickly does Salazopyrine Zetpil, Zetpillen work?
Salazopyrine Zetpil, Zetpillen start to work could be at least 12 weeks before you notice any effects. You shouldn't take Salazopyrine Zetpil, Zetpillen if you're known to have an allergy to salicylates.
When is the best time to take Salazopyrine Zetpil, Zetpillen?
It is best to take Salazopyrine Zetpil, Zetpillen right after meals, at evenly spaced times throughout the day and night. Try not to let more than 8 hours go by between doses, even at night.
Does Salazopyrine Zetpil, Zetpillen cause weight gain?
Salazopyrine Zetpil, Zetpillen can causes weight gain also with other side effects.
Is Salazopyrine Zetpil, Zetpillen a steroid?
No, Salazopyrine Zetpil, Zetpillen is not a steroid and is actually considered a "steroid-sparing" medication.
How long can I stay on Salazopyrine Zetpil, Zetpillen?
Salazopyrine Zetpil, Zetpillen takes time to work. Most patients start to feel the positive effects of at 4-8 weeks, with maximum benefit at 3-6 months.
Who should not take Salazopyrine Zetpil, Zetpillen?
If you have or have ever had asthma, kidney or liver disease, porphyria, blood problems, or blockage in your intestine or urinary tract you should not use Salazopyrine Zetpil, Zetpillen.
Does Salazopyrine Zetpil, Zetpillen cause hair loss?
Salazopyrine Zetpil, Zetpillen may not causes hair loss.
Does Salazopyrine Zetpil, Zetpillen reduce inflammation?
Salazopyrine Zetpil, Zetpillen works inside the bowels by helping to reduce the inflammation and other symptoms of the disease.
Is Salazopyrine Zetpil, Zetpillen bad for my liver?
Salazopyrine Zetpil, Zetpillen has been linked to cases of acute liver failure, particularly with hepatocellular patterns of injury.
Can Salazopyrine Zetpil, Zetpillen affect my eyes?
Salazopyrine Zetpil, Zetpillen is generally considered safe and well tolerated. There has been a report of peripheral facial nerve palsy and blurred near vision in association with Salazopyrine Zetpil, Zetpillen treatme.
How does Salazopyrine Zetpil, Zetpillen affect sperm?
Salazopyrine Zetpil, Zetpillen can decrease sperm counts and sperm motility.
How bad is Salazopyrine Zetpil, Zetpillen for you?
Salazopyrine Zetpil, Zetpillen may cause blood problems. These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums.
Can Salazopyrine Zetpil, Zetpillen cause high blood pressure?
found no effect of Salazopyrine Zetpil, Zetpillen on blood pressure, hyperemic response, or arterial diameter.
Can Salazopyrine Zetpil, Zetpillen make me infertile?
These studies confirmed the preliminary report and suggest that prolonged treatment with Salazopyrine Zetpil, Zetpillen may universally depress semen quality and cause reversible infertility.
What happens if I miss a dose?
If you forget to take a dose of Salazopyrine Zetpil, Zetpillen, take Salazopyrine Zetpil, Zetpillen as soon as you remember. If it is almost time for your next scheduled dose, take only your next dose. Do not take two doses of Salazopyrine Zetpil, Zetpillen at once.
What happens if I overdose of Salazopyrine Zetpil, Zetpillen?
Overdose symptoms may include vomiting, stomach pain, drowsiness, or seizure.
How long does it take for Salazopyrine Zetpil, Zetpillen to leave my body?
Salazopyrine Zetpil, Zetpillen is safe to just stop Salazopyrine Zetpil, Zetpillen you do not need to slowly reduce the dose. However, keep in mind, if you were gaining any benefit, it will usually take at least 6 weeks to lose it.