Sapacitabine Uses, Dosage, Side Effects and more
| Attribute | Details |
|---|---|
| Trade Name | Sapacitabine |
| Generic | Sapacitabine |
| Sapacitabine Other Names | Sapacitabine |
| Type | |
| Formula | C26H42N4O5 |
| Weight | Average: 490.645 Monoisotopic: 490.315520468 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Investigated for use/treatment in solid tumors, cutaneous t-cell lymphoma, myelodysplastic syndrome, and leukemia (lymphoid).
How Sapacitabine works
Sapacitabine appears to act through a dual mechanism. It interferes with DNA synthesis by causing single-strand DNA breaks and also induces arrest of cell cycle progression mainly at G2/M-Phase. Both sapacitabine and CNDAC, its major metabolite or a substance into which the drugs converts after ingestion by patients, have demonstrated potent anti-tumor activity in preclinical studies.
