SC-236
SC-236 Uses, Dosage, Side Effects, Food Interaction and all others data.
SC-236 is a potent, selective, orally active inhibitor of cyclooxygenase-2 (COX-2) that has been studied in cancer therapy , lower back pain , and inflammation , ,, .
| Trade Name | SC-236 |
| Generic | SC-236 |
| Type | |
| Formula | C16H11ClF3N3O2S |
| Weight | Average: 401.79 Monoisotopic: 401.02126 |
| Groups | Experimental, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
How SC-236 works
This drug is a selective inhibitor of the COX-2 enzyme , . COX-2 is expressed in the brain, in the kidney, in bone, and likely in the female reproductive system . Its expression at other sites is increased during inflammation, experimentally, in response to mitogenic stimuli. Growth factors, phorbol esters, and interleukin (IL)-1 stimulate the expression of COX-2 in fibroblasts, while endotoxin serves the same function in monocytes/macrophages .
SC-236 works also directly through suppressing the nuclear translocation of RelA/p65, a transcription factor. SC-236 directly targets proteins that facilitate the nuclear translocation of NF-κB, an inflammatory signaling pathway , .
Half Life
Long plasma half-life .
Innovators Monograph
You find simplified version here SC-236
