Selagine

Selagine Uses, Dosage, Side Effects, Food Interaction and all others data.

Selagine, is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss Huperzia serrata. The botanical has been used in China for centuries for the treatment of swelling, fever and blood disorders. Recently in clinical trials in China, it has demonstrated neuroprotective effects. It is currently being investigated as a possible treatment for diseases characterized by neurodegeneration – particularly Alzheimer’s disease.

Selagine is an alkaloid derived from Huperzia serrata (which is available as an herbal product in the US). It is under investigation as an acetylcholinesterase inhibitor. Clinical trials in China have shown that huperzine A is comparably effective to the drugs currently on the market, and may even be somewhat safer in terms of side effects.

Trade Name Selagine
Generic Huperzine A
Huperzine A Other Names Huperzine-A, L-huperzine A, Selagine
Type
Formula C15H18N2O
Weight Average: 242.3162
Monoisotopic: 242.141913208
Groups Approved, Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Selagine
Selagine

Uses

Investigated for use/treatment in alzheimer's disease.

How Selagine works

Selagine has been found to be an inhibitor of the enzyme acetylcholinesterase. This is the same mechanism of action of pharmaceutical drugs such as galantamine and donepezil used to treat Alzheimer's disease.

Innovators Monograph

You find simplified version here Selagine

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000002
http://classyfire.wishartlab.com/tax_nodes/C0001253
http://classyfire.wishartlab.com/tax_nodes/C0000056
http://classyfire.wishartlab.com/tax_nodes/C0000056
http://classyfire.wishartlab.com/tax_nodes/C0001160
http://classyfire.wishartlab.com/tax_nodes/C0003899
http://classyfire.wishartlab.com/tax_nodes/C0004144
http://classyfire.wishartlab.com/tax_nodes/C0000160
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000323
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0000469
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:78330
http://www.genome.jp/dbget-bin/www_bget?cpd:C09992
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=854026
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=175426873
https://www.chemspider.com/Chemical-Structure.16736021.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50199522
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2267703
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=78330
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL395280
https://zinc.docking.org/substances/ZINC000009411213
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/HUP
https://en.wikipedia.org/wiki/Huperzine_A
*** Taking medicines without doctor's advice can cause long-term problems.
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